Evidence map›Paper›PMID 32212069›Full record

ArticleAIDS and behavior2020

Social Support Mitigates Negative Impact of Food Insecurity on Antiretroviral Adherence Among Postpartum Women in Western Kenya.

Mira Wang, Joshua D Miller, Shalean M Collins, Marianne V Santoso, Pauline Wekesa, Hideaki Okochi, Maricianah Onono, Sheri Weiser, Monica Gandhi, Sera L Young

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in AIDS and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02974972 (Pith Moromo 2), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02974972 completednot on this map

Pith Moromo 2: Cohort to Study Health Consequences of Food and Nutrition Insecurity During Pregnancy and Lactation

TypeobservationalSponsorNorthwestern UniversityRan2014 to 2017Enrolled371ConditionsFood Insecurity, Nutrition, Maternal and Child Health, HIV
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Mira WangDepartment Anthropology, Program in Global Health, Northwestern University, Evanston, IL, 60208, USA.
Joshua D MillerDepartment Anthropology, Program in Global Health, Northwestern University, Evanston, IL, 60208, USA.ORCID http://orcid.org/0000-0002-2171-856X
Shalean M CollinsDepartment Anthropology, Program in Global Health, Northwestern University, Evanston, IL, 60208, USA.ORCID http://orcid.org/0000-0003-2991-8037
Marianne V SantosoDepartment Anthropology, Program in Global Health, Northwestern University, Evanston, IL, 60208, USA.ORCID http://orcid.org/0000-0001-6302-9116
Pauline WekesaFamily Aids Care and Education Services (FACES), Kenya Medical Research Institute, Kisumu, Kenya.
Hideaki OkochiDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Maricianah OnonoFamily Aids Care and Education Services (FACES), Kenya Medical Research Institute, Kisumu, Kenya.
Sheri WeiserDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Monica GandhiDivision of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Sera L YoungDepartment Anthropology, Program in Global Health, Northwestern University, Evanston, IL, 60208, USA. sera.young@northwestern.edu.ORCID http://orcid.org/0000-0002-1763-1218
Northwestern University · USUniversity of California, San Francisco · USKenya Medical Research Institute · KE

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 1988 to 2026
$93.6M
Plugging Hair ARV Levels as Adherence Biomarkers into HIV Prevention TrialsR01AI098472 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GANDHI, MONICA · 2012 to 2021
$5.6M
“Hair Lengthening”: Using Hair Levels to Interpret Long-Acting PrEP Studies.R37AI098472 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 2023 to 2026
$3.2M
Health Consequences of Food & Nutrition Insecurity for HIV+ Women & Their InfantsK01MH098902 · NIMH · NORTHWESTERN UNIVERSITY · PI YOUNG, SERA LEWISE · 2012 to 2016
$854k
Health consequences of water insecurity for HIV-infected mothers & their infantsR21MH108444 · NIMH · NORTHWESTERN UNIVERSITY · PI YOUNG, SERA LEWISE · 2016 to 2017
$390k
Objective measures of adherence for later-stage ART failure in resource limited settingsR03AI152773 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GANDHI, MONICA · 2020 to 2021
$161k
NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI098472NIAID NIH HHS R37 AI098472NIMH NIH HHS K01 MH098902NIMH NIH HHS K01MH098902NIMH NIH HHS R21 MH108444
6 · The paper itself

Abstract

Food insecurity (FI), low social support, and low health-related quality of life (HRQoL) are associated with self-reported nonadherence to antiretroviral therapy (ART) among postpartum women, but these relationships have not been evaluated using objective adherence indicators. Hair samples were therefore analyzed among 83 postpartum Kenyan women living with HIV on efavirenz and nevirapine ART drug regimens in an observational cohort (NCT02974972). FI (0-27), social support (0-40), and HRQoL (8-40) in the prior month were also assessed. In multivariable models, each point increase in FI and decrease in HRQoL were associated with a 45.1% (95% CI: -64.3%, -15.6%) and 10.5% decrease (95% CI: 1.0%, 22.1%) in hair ART drug concentrations respectively, when social support was held constant. A significant interaction between social support and FI (β = 0.02, p = 0.017) indicated that greater social support was predicted to mitigate the negative impacts of FI on ART adherence. Addressing these modifiable barriers could improve ART adherence during this critical period.

Indexed as

Social SupportAdultAnti-HIV AgentsFemaleFood SupplyHIV InfectionsHumansKenyaMedication AdherencePostpartum PeriodQuality of LifeSocioeconomic FactorsAnti-HIV AgentsAntiretroviral adherenceFood insecurityHair ART drug concentrationsPostpartumSocial support

Identifiers

PMID32212069
PMCPMC7483232
OpenAlexW3013642419

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.