ArticlePediatric nephrology (Berlin, Germany)2020
Born with a solitary kidney: at risk of hypertension.
Article in Pediatric nephrology (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 25 citations in OpenAlex.
- Ultrasound Doppler renal pulsatility index is a predictive marker of arterial stiffness in children with solitary functioning kidney.Jornal brasileiro de nefrologia · 2025Article
- Clinical outcomes and risk factors in pediatric patients with solitary functioning kidney: a comparative analysis of congenital and acquired etiologies.Frontiers in pediatrics · 2025Article
- [Possibilities and limitations of national guidelines based on the example of pediatric urology guidelines from the Pediatric Urology Working Group of the Austrian Society for Urology and Andrology (ÖGU)].Urologie (Heidelberg, Germany) · 2024Review
- Comparison of axial and coronal axis MRI kidney volume measurement in pediatric congenital solitary kidney.Pediatric nephrology (Berlin, Germany) · 2023Article
- Posterior Urethral Valves, Unilateral Vesicoureteral Reflux, and Renal Dysplasia (VURD) Syndrome: Long-Term Longitudinal Evaluation of the Kidney Function.International journal of environmental research and public health · 2023Article
- Management of the congenital solitary kidney: consensus recommendations of the Italian Society of Pediatric Nephrology.Pediatric nephrology (Berlin, Germany) · 2022Review
- Salt sensitivity of blood pressure in childhood and adolescence.Pediatric nephrology (Berlin, Germany) · 2022Review
- Prevalence of reflux nephropathy in Iranian children with solitary kidney: results of a multi-center study.BMC nephrology · 2022Article
- Risk stratification for children with a solitary functioning kidney.Pediatric nephrology (Berlin, Germany) · 2021Article
- Is the prognosis of congenital single functioning kidney benign? A population-based study.Pediatric nephrology (Berlin, Germany) · 2021Article
- Retrospective evaluation of children with unilateral renal agenesis.Pediatric nephrology (Berlin, Germany) · 2021Article
- Do children with solitary or hypofunctioning kidney have the same prevalence for masked hypertension?Pediatric nephrology (Berlin, Germany) · 2021Article
- Clinical Management of Children with a Congenital Solitary Functioning Kidney: Overview and Recommendations.European urology open science · 2021Review
- Cardiovascular risk assessment in children and adolescents with congenital solitary kidneys.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Physiology and Pathophysiology of Compensatory Adaptations of a Solitary Functioning Kidney.Frontiers in physiology · 2020Review
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSubjects with a congenital solitary kidney (CSK) are believed to be at risk of hypertension due to their low number of nephrons. However, as CSK is a congenital abnormality of the kidney or urinary tract (CAKUT), subtle dysplastic changes contributing to hypertension cannot be excluded.
methodsWe retrospectively compared office blood pressure (OBP) and ambulatory blood pressure monitoring (ABPM) between two groups of children with CAKUT, aged 6-18 years: Group A with a CSK and Group B with two kidneys. All had normal renal parenchyma on scintigraphy and normal renal function. OBP and mean systolic and diastolic 24-h, daytime and nighttime ambulatory BP records were analyzed. The distribution of OBP and APBM as continuous values and the prevalence of hypertension (ambulatory/severe ambulatory or masked hypertension) in the two groups were compared.
resultsThere were 81 patients in Group A and 45 in Group B. Median OBP standard deviation scores were normal in both groups, without significant differences. Median ABPM standard deviation scores, although normal, were significantly higher in Group A and the prevalence of hypertension was higher (ambulatory/severe ambulatory or masked) (33.3 vs. 13.3%, p = 0.019), mainly because of the greater occurrence of masked hypertension.
conclusionsOur data show that a CSK per se can be associated with an increased risk of hypertension from the pediatric age. Therefore, ABPM, which has proved valuable in the screening of hypertension, is warranted in children with a CSK, even if laboratory and imaging assessment is otherwise normal.
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