ArticleArchives of gynecology and obstetrics2020
Impact of embryo quality and endometrial thickness on implantation in natural cycle IVF.
Article in Archives of gynecology and obstetrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Impact of endometrial thickness on reproductive outcome in fresh and frozen-thawed embryo transfer: systematic review and meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Pooled it
- The Effect of Endometrial Thickness on Pregnancy, Maternal, and Perinatal Outcomes of Women in Fresh Cycles After IVF/ICSI: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- How endometrial thickness affects pregnancy and perinatal outcomes: a retrospective study of 16,566 frozen-thawed single blastocyst transfer cycles.Reproductive biology and endocrinology : RB&E · 2026Article
- mTORC1 as a metabolic rheostat coordinates hormonal signals and cellular proliferation to sustain endometrial competence.Cellular & molecular biology letters · 2026Article
- A prospective pilot study on DACHAO intervention for improving embryo quality metrics in IVF/ICSI failure cases.Frontiers in cell and developmental biology · 2026Article
- Analysis of related factors of biochemical pregnancy loss in single blastocyst transfer in the hormone replacement protocol frozen-thawed cycle.BMC pregnancy and childbirth · 2025Article
- Linear association between endometrial thickness and live birth in single blastocyst transfers: A dual-center retrospective cohort study.Acta obstetricia et gynecologica Scandinavica · 2025Article
- MicroRNAs Secreted by the Embryo in Spent Culture Medium Can Regulate mRNAs Involved in Endometrial Receptivity, Embryo Attachment, and Invasion.International journal of molecular sciences · 2025Article
- Platelet-rich plasma therapy for thin endometrium: a comprehensive review.Archives of gynecology and obstetrics · 2025Review
- Stem cell treatments for female reproductive disorders: a comprehensive review.Journal of ovarian research · 2025Review
- Effectiveness and safety of consecutive single embryo transfer compared to double embryo transfer: results from the UK HFEA registry.Human reproduction (Oxford, England) · 2025Article
- Unlocking Therapeutic Potential: Mesenchymal Stem Cells-derived Exosomes in IUA Treatment, Current Status and Perspectives.Current pharmaceutical design · 2025Review
- Association between pretransfer cleavage-stage blastomere dynamics and pregnancy outcomes in fresh single embryo transfer cycles: a retrospective cohort study.Frontiers in endocrinology · 2025Article
- Effect of blastomere cell number on ART outcome of fresh single day 3 embryo transfer.BMC pregnancy and childbirth · 2024Article
- The construction of machine learning-based predictive models for high-quality embryo formation in poor ovarian response patients with progestin-primed ovarian stimulation.Reproductive biology and endocrinology : RB&E · 2024Article
- Endometrial receptivity in women of advanced age: an underrated factor in infertility.Human reproduction update · 2023Review
- A critical appraisal of studies on endometrial thickness and embryo transfer outcome.Reproductive biomedicine online · 2023Review
- Development speed of sibling embryo positively reflects live birth rate after fresh day 3 embryo transfer.Scientific reports · 2023Article
- The influence of day 3 embryo cell number on the clinical pregnancy and live birth rates of day 5 single blastocyst transfer from frozen embryo transfer cycles.BMC pregnancy and childbirth · 2022Article
- Comparison of clinical effects between early follicular prolonged GnRH agonist protocol and GnRH antagonist protocol in 3310 cycles: a retrospective study.BMC pregnancy and childbirth · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study is to assess the effect of the endometrial thickness and embryo quality on the implantation potential in natural cycle IVF (NC-IVF).
methodsA retrospective single-center study was performed on 552 single embryo transfers after NC-IVF. The 'quality' of the embryos was evaluated trough the number and regularity of blastomeres, degree of fragmentation, and nuclear content of cells. Endometrial thickness was measured in millimeters with transvaginal ultrasound on the day of hCG application.
resultsOur findings showed a statistically significant difference in successful implantation until a plateau of 10 mm is reached (p = 0.001). Only one pregnancy was achieved where endometrial thickness was less than 7 mm, and this resulted in an early miscarriage. The predictors of favorable implantation were fragmentation (≤ 10%, p < 0.05) and the number of blastomeres (preferably 8-cell, p < 0.01) on day 3. Embryo quality (R = 0.052) and endometrial thickness (R = 0.18) were closely related to pregnancy rate. The overall implantation rate per embryo transfer was 18.8%.
conclusionsEmbryo quality and endometrial thickness have a significant impact on implantation in NC-IVF. Highest implantation potential has an 8-cell embryo with ≤ 10% fragmentation in the third day following oocyte retrieval. Endometrial thickness of at least 7 mm seems to be the optimal edge of successful pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.