ArticleThe Journal of infectious diseases2022
Dengue Endemicity, Force of Infection, and Variation in Transmission Intensity in 13 Endemic Countries.
Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- The epidemiologic and economic burden of dengue in Singapore: A systematic review.PLoS neglected tropical diseases · 2024Pooled it
- Viral Dynamic Model-Informed Dose Selection of Mosnodenvir Prophylaxis against DENV-3 in a Controlled Human Infection Model.Clinical pharmacology and therapeutics · 2026Trial
- Sero-catalytic and spatial modeling of dengue virus force of infection in Timor-Leste.Nature communications · 2026Article
- Addressing Knowledge, Attitudes and Practices Toward Dengue Fever, Vector Control, and Vaccine Acceptance Among the General Population in Singapore.Tropical medicine and infectious disease · 2026Article
- Zika Virus Neutralizing Antibody Responses Elicited by Vaccination or Infection.Open forum infectious diseases · 2025Article
- Entomological surveys and insecticide resistance in the dengue vector Aedes aegypti in Dakar, Senegal: First detection of the kdr mutation.PLoS neglected tropical diseases · 2025Article
- Force of Infection Model for Estimating Time to Dengue Virus Seropositivity among Expatriate Populations, Thailand.Emerging infectious diseases · 2025Article
- Age-time-specific transmission of hand-foot-and-mouth disease enterovirus serotypes in Vietnam: A catalytic model with maternal immunity.Epidemics · 2024Article
- Direct and indirect effects of age on dengue severity: The mediating role of secondary infection.PLoS neglected tropical diseases · 2023Article
- Repeated Rapid Active Sampling Surveys Demonstrated a Rapidly Changing Zika Seroprevalence among Children in a Rural Dengue-endemic Region in Southwest Guatemala during the Zika Epidemic (2015-2016).The American journal of tropical medicine and hygiene · 2022Article
- Time-dependent force of infection and effective reproduction ratio in an age-structure dengue transmission model in Bandung City, Indonesia.Infectious Disease Modelling · 2022Article
- Serology as a Tool to Assess Infectious Disease Landscapes and Guide Public Health Policy.Pathogens (Basel, Switzerland) · 2022Review
- Spatiotemporal variations in exposure: Chagas disease in Colombia as a case study.BMC medical research methodology · 2022Article
- Assessing the burden of dengue among household members in Alaminos, Laguna, the Philippines: a prospective cohort study.Asian biomedicine : research, reviews and news · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue endemicity varies but comparative, multicountry data are extremely limited. An improved understanding is needed to prioritize prevention, including vaccination, which is currently recommended only under specific epidemiological conditions. We used serological study data from 46 geographical sites in 13 countries to estimate dengue force of infection (FOI, the proportion of children seroconverting per year) under assumptions of either age-constant or age-varying FOI, and the age at which 50% and 80% of children had been infected. After exclusions, 13 661 subjects were included. Estimated constant FOI varied widely, from 1.7% (Singapore) to 24.1% (the Philippines). In the site-level analysis 44 sites (96%) reached 50% seroconversion and 35 sites (75%) reached 80% seroconversion by age 18 years, with significant heterogeneity. These findings confirm that children living in dengue-endemic countries receive intense early dengue exposure, increasing risk of secondary infection, and imply serosurveys at fine spatial resolutions are needed to inform vaccination campaigns.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.