ArticleJOR spine2020
Spinopelvic alignment predicts disc calcification, displacement, and Modic changes: Evidence of an evolutionary etiology for clinically-relevant spinal phenotypes.
Article in JOR spine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Clinical study on the 3D morphology and mechanical factors of lumbar facet joints in patients with degenerative lumbar spondylolisthesis.Bone & joint research · 2026Article
- The triadic relationship between spinal posture, loading, and degeneration.Frontiers in bioengineering and biotechnology · 2025Article
- Intradiscal vacuum phenomenon matches lumbar spine degeneration patterns in an ageing population.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Review
- A new perspective on intervertebral disc calcification-from bench to bedside.Bone research · 2024Review
- Focusing on the amount of immediate changes in spinopelvic radiographic parameters to predict the amount of mid-term improvement of quality of life in adult degenerative scoliosis patients with surgery.Archives of orthopaedic and trauma surgery · 2023Article
- 5-Year progression prediction of endplate defects: Utilizing the EDPP-Flow convolutional neural network based on unbalanced data.Journal of orthopaedics · 2023Article
- Learning-based fully automated prediction of lumbar disc degeneration progression with specified clinical parameters and preliminary validation.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Article
- Mechanisms and clinical implications of intervertebral disc calcification.Nature reviews. Rheumatology · 2022Review
- Basivertebral Nerve Ablation for the Treatment of Vertebrogenic Pain.Pain and therapy · 2021Review
- Correlation of Modic Changes with Sagittal Lumbopelvic Parameters.Journal of pain research · 2021Article
- Article
- Modic changes - An evidence-based, narrative review on its patho-physiology, clinical significance and role in chronic low back pain.Journal of clinical orthopaedics and traumaArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lumbar disc-displacement, Modic changes (MCs), and UTE Disc Sign (UDS) on MRI are clinically relevant spinal phenotypes that can lead to sciatica/LBP. Not all degenerated discs result in disc-displacement, MCs and UDS, suggesting varied etiologies. Spinopelvic parameters have been implicated in various spinal disorders. Pelvic incidence (PI) is "fixed parameter" since skeletal maturity. No study has addressed disc-displacement, MCs and UDS in context of spinopelvic parameters. Therefore, the aim of study was to determine if spinopelvic parameters are associated and predict clinically-relevant MRI-phenotypes. One hundred and eight population-based subjects (mean age: 52.3 years) were recruited. Spondylolisthesis and scoliosis individuals were excluded. Lumbar lordosis (LL), PI, sacral slope (SS), and pelvic tilt (PT) were assessed on lateral plain radiographs. Disc degeneration was assessed and summated, and presence or not of disc-displacement and MCs were noted on T2W MRI. UDS was detected on UTE. Following exclusion criteria, 95 subjects were assessed. Disc-displacement (82.1%), MCs (52.6%), and UDS (37.9%) were associated with lower PI, SS, LL, and LL/PI index. On multivariate analyses, lower PI was significantly related to development of these MRI phenotypes (adjusted OR range:0.95-0.92;
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