Evidence map›Paper›PMID 32211584›Full record

ArticleJNCI cancer spectrum2020

Association Between Outdoor Air Pollution and Risk of Malignant and Benign Brain Tumors: The Multiethnic Cohort Study.

Anna H Wu, Jun Wu, Chiuchen Tseng, Juan Yang, Salma Shariff-Marco, Scott Fruin, Timothy Larson, Veronica W Setiawan, Shahir Masri, Jacqueline Porcel and 6 more

Open access · goldAbstract read
In one paragraph

Article in JNCI cancer spectrum, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Impact of Pollution on Cancer: A Systematic Review and Meta-Analysis with Focus on Air Pollution.International journal of environmental research and public health · 2026
    Pooled it
  2. Ambient Air Pollution and Risk of Brain Tumors: A Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2026
    Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Air Pollution and Breast Cancer Incidence in the Multiethnic Cohort Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Article
  9. Article
  10. Article
  11. Impacts of Environmental Pollution on Brain Tumorigenesis.International journal of molecular sciences · 2023
    Review
  12. Article
  13. Traffic-related Air Pollution and Lung Cancer Incidence: The California Multiethnic Cohort Study.American journal of respiratory and critical care medicine · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave, Rm 4443, Los Angeles, CA 90089, USA.ORCID 0000-0003-0546-902X
Jun WuProgram in Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Anteater Instruction & Research Bldg (AIRB) # 2034, 653 East Peltason Drive, Irvine, CA 92697-3957, USA.
Chiuchen TsengDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave, Rm 4443, Los Angeles, CA 90089, USA.
Juan YangDepartment of Epidemiology and Biostatistics, University of California, 550 16th Street, Box 0560, San Francisco, CA 94158, USA.
Salma Shariff-MarcoDepartment of Epidemiology and Biostatistics, University of California, 550 16th Street, Box 0560, San Francisco, CA 94158, USA.
Scott FruinDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave, Rm 4443, Los Angeles, CA 90089, USA.ORCID 0000-0002-2953-0457
Timothy LarsonDepartment of Civil & Environmental Engineering, University of Washington, 269 Wilcox Hall Box352700, School of Public Health, Seattle, WA 98195, USA.ORCID 0000-0003-2208-982X
Veronica W SetiawanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave, Rm 4443, Los Angeles, CA 90089, USA.
Shahir MasriProgram in Public Health, Susan and Henry Samueli College of Health Sciences, University of California, Anteater Instruction & Research Bldg (AIRB) # 2034, 653 East Peltason Drive, Irvine, CA 92697-3957, USA.
Jacqueline PorcelDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave, Rm 4443, Los Angeles, CA 90089, USA.ORCID 0000-0002-0538-7393
Jennifer JainFrontdoor Inc, 150 Peabody Place, Memphis, TN 38103, USA.
Thomas C ChenDepartment of Neurological Surgery, Keck School of Medicine, University of Southern California, GNH 3300, Mail code, Los Angeles, CA 90089-9314, USA.
Daniel O StramDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave, Rm 4443, Los Angeles, CA 90089, USA.
Loïc Le MarchandEpidemiology Program, University of Hawaii Cancer Center, 701 Ilalo Street. Honolulu, HI 96813, USA.
Beate RitzDepartment of Epidemiology, School of Public Health, University of California, 650 Charles Young Dr. South, Los Angeles, CA 90095-1772, USA.
Iona ChengDepartment of Epidemiology and Biostatistics, University of California, 550 16th Street, Box 0560, San Francisco, CA 94158, USA.ORCID 0000-0003-4132-2893
University of Southern California · USUniversity of California, San Francisco · USSamueli Institute · USUniversity of California, Los Angeles · USUniversity of Hawaiʻi at Mānoa · USUniversity of Washington · US

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
Exposure to mobile source air pollution and adverse birth outcomes in the Los AngR21ES016379 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI WU, JUN · 2008 to 2009
$552k
Historic Traffic Exposure Maps for Cancer StudiesR21CA094723 · NCI · IMPACT ASSESSMENT, INC. · PI ENGLISH, PAUL B · 2001 to 2003
$449k
NCI NIH HHS P30 CA014089NCI NIH HHS R21 CA094723NCI NIH HHS U01 CA164973NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R21 ES016379
6 · The paper itself

Abstract

backgroundThere are increasing concerns about the potential impact of air pollution on chronic brain inflammation and microglia cell activation, but evidence of its carcinogenic effects is limited.

methodsWe used kriging interpolation and land use regression models to estimate long-term air pollutant exposures of oxides of nitrogen (NO

resultsBrain cancer risk in men increased in association with exposure to benzene (hazard ratio [HR] = 3.52, 95% confidence interval [CI] = 1.55 to 7.55) and PM

conclusionsConfirmation of these sex differences in air pollution-brain cancer associations and the stronger findings in Latino men in additional diverse populations is warranted.

Identifiers

PMID32211584
PMCPMC7083235
OpenAlexW2998578827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.