ArticleJNCI cancer spectrum2020
A Case-Control Study Examining Disparities in Clinical Trial Participation Among Breast Surgical Oncology Patients.
Article in JNCI cancer spectrum, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of socioeconomic status on enrollment in clinical trials for cancer: A systematic review.Cancer medicine · 2024Pooled it
- The right patient, the right moment, the right therapy: reimagining precision oncology from the bedside.Cancer metastasis reviews · 2026Review
- Association between self-reported breast cancer knowledge and clinical trial participation in patients with triple-negative breast cancer.Breast cancer research and treatment · 2026Article
- A Sensitivity Analysis Framework Using the Proxy Pattern-Mixture Model for Generalization of Experimental Results.Statistics in medicine · 2025Article
- Are those all my options? Evaluating oncologists' communication strategies in treatment and clinical trial discussions by race and gender.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Observational
- The role of social, economic, and medical marginalization in cancer clinical trial participation inequities: A systematic review.Journal of clinical and translational science · 2025Review
- Mediators of racial and ethnic inequities in clinical trial participation among patients with cancer, 2011-2023.JNCI cancer spectrum · 2024Article
- Trends and Disparities in Clinical Trial Enrollment as Part of First-Line Treatment for Upper Gastrointestinal and Hepatopancreatobiliary Malignancies.Annals of surgical oncology · 2023Article
- Investigating potential disparities in clinical trial eligibility and enrollment at an NCI-designated comprehensive cancer center.Cancer medicine · 2023Article
- Breast cancer among African American and sub-Saharan African women: a tale of global inequities.Cancer causes & control : CCC · 2022Article
- Article
- A population-based study of invitation to and participation in clinical trials among women with early-stage breast cancer.Breast cancer research and treatment · 2020Article
- Adult neuro-oncology trials in the United States over 5 decades: Analysis of trials completion rate to guide the path forward.Neuro-oncology advancesArticle
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
backgroundClinical trial participation among racial and ethnic minorities remains low despite national efforts. We sought to determine how participation in clinical trials by breast surgical oncology patients has changed over time and what characteristics are associated with participation.
methodsWomen with breast cancer enrolled in National Cancer Institute-sponsored, cooperative-group trials from 2000 to 2012 and who underwent oncologic surgery (n = 17 125) were compared with trial-eligible women in the National Cancer Database diagnosed in 2000-2012 (n = 792 719). Race-specific trial participation was plotted over time by income and reported as a proportion of the combined cohorts. Factors associated with trial participation were estimated using logistic regression; we report odds ratios (ORs) with 95% confidence intervals (CIs). A
resultsParticipation declined across all groups over time because of a decrease in the scale and number of trials. In 2000-2003, Asian-Pacific Islander (7.17%), Hispanic (3.48%), and white (7.13%) patients from the highest income group had higher participation than their lower-income counterparts (Asian-Pacific Islander: 3.95%; Hispanic: 2.67%; white: 5.96%), but by 2008-2012, only high-income white patients participated more than lower-income whites (0.32% vs 0.25%, all
conclusionsMultifaceted interventions addressing the intersectionality of race, ethnicity, and other patient characteristics are needed to address persistent disparities in trial participation among breast surgical oncology patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.