Evidence map›Paper›PMID 32211568›Full record

ArticleAdvanced research in gastroenterology & hepatology2019

Opposing Roles of BMP and TGF-β Signaling Pathways in Pancreatitis: Mechanisms and Therapeutic Implication.

Yanna Cao, Madeline Drake, Joy Davis, Baibing Yang, Tien C Ko

Open access · diamondAbstract read
PubMed Full text at PMC
In one paragraph

Article in Advanced research in gastroenterology & hepatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yanna CaoDepartment of Surgery, The University of Texas Health Science Center, USA.
Madeline DrakeDepartment of Surgery, The University of Texas Health Science Center, USA.
Joy DavisDepartment of Surgery, The University of Texas Health Science Center, USA.
Baibing YangDepartment of Surgery, The University of Texas Health Science Center, USA.
Tien C KoDepartment of Surgery, The University of Texas Health Science Center, USA.
The University of Texas Health Science Center at Houston · US

Funding

Protective Signaling Pathway in Alcohol-Induced PancreatitisR21AA027014 · NIAAA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KO, TIEN C · 2019 to 2020
$406k
NIAAA NIH HHS R21 AA027014
6 · The paper itself

Abstract

Bone morphogenetic proteins (BMPs) comprise a major subgroup of the transforming growth factor (TGF)-β superfamily. They play pivotal roles in embryonic development and tissue homeostasis in adults. Deregulation of BMP and TGF-β signaling contributes to developmental anomalies and multiple diseases. In this mini-review, we focus on BMP signaling in inflammatory disorders of the pancreas, acute and chronic pancreatitis, in contrast to TGF-β signaling. We then discuss molecular mechanisms that interact with and connect between the BMP and TGF-β signaling pathways. Lastly, we review potential implications of these molecular mechanisms for therapeutic development. In summary, BMP signaling pathway plays different roles during pancreatitis disease development, and the antagonism between BMP and TGF-β signaling can be manipulated for therapeutic development against pancreatitis.

Indexed as

AcuteAntibodyBone morphogenetic proteinChronicFibrosisGremlin 1InflammationPancreatic stellate cellsPancreatitisTransforming growth factor-beta

Identifiers

PMID32211568
PMCPMC7093075
OpenAlexW3014225903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.