ArticleCurrent opinion in biomedical engineering2020
Connective Tissue Remodeling in Myopia and its Potential Role in Increasing Risk of Glaucoma.
Article in Current opinion in biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Advances in glaucoma biomechanics from 2000 to 2024: a bibliometric study and visualization analysis.Frontiers in neuroscience · 2025Pooled it
- Shared genetic architecture of hernias: A genome-wide association study with multivariable meta-analysis of multiple hernia phenotypes.PloS one · 2022Pooled it
- A Comprehensive Assessment of the Shared Genetic Architecture between Myopia and Open-Angle Glaucoma.Ophthalmology science · 2026Article
- Role of bruch's membrane opening area: a clinical indicator of the progression of macular defects in high myopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Localized Choriocapillaris Flow Deficits at Perforating Vessel Sites in Myopic Eyes.Investigative ophthalmology & visual science · 2026Article
- Peripapillary scleral stiffening increases optic nerve head shear deformation in porcine eyes during IOP elevation.Experimental eye research · 2025Article
- Progressive Ocular Axial Elongation and Retinal Ganglion Cell Degeneration in Mice with Elastic Fiber Disorder.International journal of molecular sciences · 2025Article
- Independent Effects of Axial Length and Intraocular Pressure on the Highly Myopic Optic Nerve Head.Investigative ophthalmology & visual science · 2025Article
- Early Peripapillary Choroidal Thinning during Myopia Development: A Potential Biomarker for Progressive Myopia Identified in Tree Shrews.Investigative ophthalmology & visual science · 2025Article
- Multiscale analysis of equatorial sclera anisotropy: Revealing discrepancies in fiber orientation and mechanical properties.Science advances · 2025Article
- Gaze-Induced Optic Nerve Head Deformations Are Greater in High Myopia and Strains Increase With Axial Length.Investigative ophthalmology & visual science · 2025Article
- Asymmetric stress distribution on lamina cribrosa in glaucoma patients with high myopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Impact of Optic Nerve Tortuosity, Globe Proptosis, and Size on Retinal Ganglion Cell Thickness Across General, Glaucoma, and Myopic Populations.Investigative ophthalmology & visual science · 2025Article
- Reticular fiber distribution in sclera: Key to understanding pathologic myopia and posterior staphylomas.Molecular vision · 2025Article
- Mechanobiology in the eye.npj biological physics and mechanics · 2025Review
- Diagnostic challenges in high myopia: identification of sight-threatening complications and the role of artificial intelligence.Frontiers in ophthalmology · 2025Review
- Comparing IOP-Induced Scleral Deformations in the Myopic and Myopic Glaucoma Spectrums.Investigative ophthalmology & visual science · 2024Article
- Sustained Retinal Defocus Increases the Effect of Induced Myopia on the Retinal Astrocyte Template.Cells · 2024Article
- IOP and glaucoma damage: The essential role of optic nerve head and retinal mechanosensors.Progress in retinal and eye research · 2024Review
- Heterogenous thinning of peripapillary tissues occurs early during high myopia development in juvenile tree shrews.Experimental eye research · 2024Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Myopia and glaucoma are both increasing in prevalence and are linked by an unknown mechanism as many epidemiologic studies have identified moderate to high myopia as an independent risk factor for glaucoma. Myopia and glaucoma are both chronic conditions that lead to connective tissue remodeling within the sclera and optic nerve head. The mechanobiology underlying connective tissue remodeling differs substantially between both diseases, with different homeostatic control mechanisms. In this article, we discuss similarities and differences between connective tissue remodeling in myopia and glaucoma; selected multi-scale mechanisms that are thought to underlie connective tissue remodeling in both conditions; how asymmetric remodeling of the optic nerve head may predispose a myopic eye for pathological remodeling and glaucoma; and how neural tissue deformations may accumulate throughout both pathologies and increase the risk for mechanical insult of retinal ganglion cell axons.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.