Evidence map›Paper›PMID 32211511›Full record

ArticleInternational journal of cardiology. Heart & vasculature2020

Multifocal cardiovascular calcification in patients with established cardiovascular disease; prevalence, risk factors, and relation with recurrent cardiovascular disease.

Cilie C van 't Klooster, Hendrik M Nathoe, J Hjortnaes, Michiel L Bots, Ivana Isgum, Nikolas Lessmann, Yolanda van der Graaf, Tim Leiner, Frank L J Visseren, UCC-SMART-study group

Open access · goldAbstract read
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In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Cilie C van 't KloosterDepartment of Vascular Medicine, University Medical Center Utrecht (UMCU), Utrecht University, the Netherlands.
Hendrik M NathoeDepartment of Cardiology, University Medical Center Utrecht (UMCU), Utrecht University, the Netherlands.
J HjortnaesDepartment of Cardiothoracic Surgery, University Medical Center Utrecht (UMCU), Utrecht University, the Netherlands.
Michiel L BotsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht (UMCU), Utrecht University, the Netherlands.
Ivana IsgumImage Sciences Institute, University Medical Center Utrecht (UMCU), Utrecht University, the Netherlands.
Nikolas LessmannImage Sciences Institute, University Medical Center Utrecht (UMCU), Utrecht University, the Netherlands.
Yolanda van der GraafJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht (UMCU), Utrecht University, the Netherlands.
Tim LeinerDepartment of Radiology, University Medical Center Utrecht (UMCU), Utrecht University, the Netherlands.
Frank L J VisserenDepartment of Vascular Medicine, University Medical Center Utrecht (UMCU), Utrecht University, the Netherlands.
UCC-SMART-study group
Utrecht University · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe aim is to investigate (multifocal) cardiovascular calcification in patients with established cardiovascular disease (CVD), regarding prevalence, risk factors, and relation with recurrent CVD or vascular interventions. Coronary artery calcification (CAC), thoracic aortic calcification (TAC) (including ascending aorta, aortic arch, descending aorta), mitral annular calcification (MAC), and aortic valve calcification (AVC) are studied.

methodsThe study concerned 568 patients with established CVD enrolled in the ORACLE cohort. All patients underwent computed tomography. Prevalence of site-specific and multifocal calcification was determined. Ordinal regression analyses were performed to quantify associations of risk factors with cardiovascular calcification, and Cox regression analyses to determine the relation between calcium scores and recurrent CVD or vascular interventions.

resultsCalcification was multifocal in 76% (N = 380) of patients with calcification. Age (per SD) was associated with calcification at all locations (lowest OR 2.17; 99%CI 1.54-3.11 for ascending aorta calcification). Diabetes mellitus and systolic blood pressure were associated with TAC, whereas male sex was a determinant of CAC. TAC and CAC were related to the combined endpoint CVD or vascular intervention (N = 68). In a model with all calcium scores combined, only CAC was related to the combined outcome (HR 1.39; 95%CI 1.15-1.68).

conclusionCardiovascular calcification is generally multifocal in patients with established CVD. Differences in associations between risk factors and calcification at various anatomical locations stress the divergence in pathophysiological pathways. CAC is most strongly related to recurrent CVD or vascular interventions independent of traditional risk factors, and independent of heart valve and thoracic aorta calcification.

Indexed as

Multifocal cardiovascular calcificationPatients with established cardiovascular diseasePrevalenceRecurrent cardiovascular diseaseRisk factors

Identifiers

PMID32211511
PMCPMC7082515
OpenAlexW3012164186

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.