ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
Genetic and regulatory architecture of Alzheimer's disease in the
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 32 citations in OpenAlex.
- Novel Alzheimer's disease-associated variants and genetic interactions identified from UK biobank whole-exome sequencing data using IBI-DT.Scientific reports · 2026Article
- Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America.Nature aging · 2026Article
- Lower hippocampal volume partly mediates the association between rs6859 in theFrontiers in aging neuroscience · 2026Article
- Associations of Alzheimer's disease with inpatient hospital costs and with quality-adjusted life years: evidence from conventional and Mendelian randomization analyses in the UK Biobank.Cost effectiveness and resource allocation : C/E · 2025Article
- PolyGR-containing aggregates link with pathology and clinical features of Alzheimer's disease.Acta neuropathologica · 2025Article
- Lower Hippocampal Volume Partly Mediates the Association Between rs6859 in themedRxiv : the preprint server for health sciences · 2025Article
- Multivariable Mendelian randomization study supports the causal effects of circulating metabolites on frailty.Aging clinical and experimental research · 2025Article
- Distinct gut microbiota profiles and network properties in older Korean individuals with subjective cognitive decline, mild cognitive impairment, and Alzheimer's disease.Alzheimer's research & therapy · 2025Article
- Trustworthy causal biomarker discovery: a multiomics brain imaging genetics-based approach.Bioinformatics (Oxford, England) · 2025Article
- A Module-Level Polygenic Risk Score-Based NetWAS Framework for Identifying AD Genetic Modules Mediated by Amygdala: An ADNI Study.International journal of molecular sciences · 2025Article
- Comparison of Ensemble Techniques for Early Prediction of Alzhiemer Disease.Research square · 2024Article
- Assessing polyomic risk to predict Alzheimer's disease using a machine learning model.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The genetic landscape of basal ganglia and implications for common brain disorders.Nature communications · 2024Article
- BEATRICE: Bayesian fine-mapping from summary data using deep variational inference.Bioinformatics (Oxford, England) · 2024Article
- Network medicine-based epistasis detection in complex diseases: ready for quantum computing.Nucleic acids research · 2024Article
- BEATRICE: Bayesian Fine-mapping from Summary Data using Deep Variational Inference.bioRxiv : the preprint server for biology · 2024Article
- Modeling genotype-protein interaction and correlation for Alzheimer's disease: a multi-omics imaging genetics study.Briefings in bioinformatics · 2024Article
- Network medicine-based epistasis detection in complex diseases: ready for quantum computing.medRxiv : the preprint server for health sciences · 2023Article
- Incorporating multi-stage diagnosis status to mine associations between genetic risk variants and the multi-modality phenotype network in major depressive disorder.Frontiers in psychiatry · 2023Article
- Association of APOE Serum Levels andGenes · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
introductionApolipoprotein E (
methodsWe examined differences in linkage disequilibrium (LD) structures between (1) AD-affected and unaffected subjects and (2) older AD-unaffected and younger subjects in the 19q13.3 region harboring rs7412 and rs429358.
resultsAD is associated with sex-nonspecific heterogeneous patterns of decreased and increased LD of rs7412 and rs429358, respectively, with other polymorphisms from five genes in this region in AD-affected subjects. The LD patterns in older AD-unaffected subjects resembled those in younger individuals. Polarization of the ε4- and ε2 allele-related heterogeneous LD clusters differentiated cell types and implicated specific tissues in AD pathogenesis. DISCUSSION: Protection and predisposition to AD is characterized by an interplay of rs7412 and rs429358, with multiple polymorphisms in the 19q13.3 region in a tissue-specific manner, which is not driven by common evolutionary forces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.