ArticleVirusdisease2020
Genetic and evolutionary analysis of enterovirus 71 base dinucleotide.
Article in Virusdisease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, a comprehensive analysis of genome sequences of 99 EV71 virus isolates base dinucleotide odds ratio was conducted to explore the potential mechanisms of its evolution. The general correlation of dinucleotides at different sites of the codons reveals that mutational pressure is the main factor determining EV 71 evolution. Furthermore, the apparent geographic segmentation of isolates before 2008 and low-frequency appearance of TpA and CpG also suggest that the geographic and host factors play important roles in the evolution of the virus. Finally, obvious fluctuation and divergence of the dinucleotide usage pattern was observed in the EV71 isolated in China after 2008, which might reveal that the virus entered a rapid evolution period, especially after 2010. These results indicate that EV71 has more initiative and adaptability under external pressures.
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