ArticleERJ open research2020
12-year adherence to inhaled corticosteroids in adult-onset asthma.
Article in ERJ open research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The trial behind it
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Treatment response and determinants of asthma control in Eastern Africa.BMC pulmonary medicine · 2026Article
- Adherence to asthma medication and asthma control in Finland.BMC pulmonary medicine · 2026Article
- Stability of Type 2 Inflammation in a 12-Year Adult-Onset Asthma Follow-Up Study.Journal of asthma and allergy · 2026Article
- Risk factors for asthma exacerbations.The journal of allergy and clinical immunology. Global · 2025Article
- No Improvement of Asthma Control Despite Changes in Pharmacological Treatment Patterns - 17 Years Follow Up.Journal of asthma and allergy · 2025Article
- Best practice advice for asthma exacerbation prevention and management in primary care: an international expert consensus.NPJ primary care respiratory medicine · 2024Review
- Comorbidities associated with adult asthma: a population-based matched cohort study in Finland.BMJ open respiratory research · 2024Article
- Documentation of comorbidities, lifestyle factors, and asthma management during primary care scheduled asthma contacts.NPJ primary care respiratory medicine · 2024Article
- Real-world use and perceptions of shared decision-making for allergy and asthma care in a US population.The World Allergy Organization journal · 2023Article
- Adherence to treatment guidelines and good asthma control in Finland.European clinical respiratory journal · 2023Article
- Defined daily dose definition in medication adherence assessment in asthma.European clinical respiratory journal · 2023Article
- Documentation of smoking in scheduled asthma contacts in primary health care: a 12-year follow-up study.NPJ primary care respiratory medicine · 2022Article
- Understanding relationships between asthma medication use and outcomes in a SABINA primary care database study.NPJ primary care respiratory medicine · 2022Article
- Assessing adherence to inhaled therapies in asthma and the emergence of electronic monitoring devices.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- House Dust Mite Subcutaneous Immunotherapy and Lung Function Trajectory in Children and Adolescents with Asthma.Children (Basel, Switzerland) · 2022Article
- Participation in scheduled asthma follow-up contacts and adherence to treatment during 12-year follow-up in patients with adult-onset asthma.BMC pulmonary medicine · 2022Observational
- Determining Persistence with an Inhaled Corticosteroid in Asthma: Assessment Using an Objective Measurement vs the Self-Reported Foster Score.Journal of asthma and allergy · 2022Article
- Pattern of treatment of behavioural and psychological symptoms of dementia and pain: evidence on pharmacoutilization from a large real-world sample and from a centre for cognitive disturbances and dementia.European journal of clinical pharmacology · 2021Observational
- Long-term adherence to inhaled corticosteroids and asthma control in adult-onset asthma.ERJ open research · 2021Article
- Assessment of adherence to corticosteroids in asthma by drug monitoring or fractional exhaled nitric oxide: A literature review.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adherence to inhaled corticosteroids (ICS) has been suggested to be poor but long-term follow-ups are lacking. The objective of the present study was to assess adherence to ICS treatment in patients with adult-onset asthma during 12-year follow-up. A total of 181 patients with clinically confirmed, new-onset adult asthma were followed for 12 years as part of the Seinäjoki Adult Asthma Study. Adherence to ICS was assessed individually as the percentage of true dispensed ICS in micrograms per true prescribed daily ICS in micrograms over 12 years. Mean 12-year adherence to ICS was 69% (mean±sd dispensed 2.5±1.8 g and prescribed 3.6±1.5 g budesonide equivalent per patient for 12 years), annual adherence varying between 81% (year 1) and 67% (year 12). Patients with good 12-year adherence (≥80%) used oral corticosteroids more often, and had add-on drugs in use and asthma-related visits to healthcare more often. In addition, they showed less reversibility in forced expiratory volume in 1 s and had higher peripheral blood neutrophil counts. However, lung function decline was steeper in patients with poorer adherence (<80%) and this association remained in multiple linear regression analysis. No difference was found in symptom scores, blood eosinophil counts, exhaled nitric oxide or immunoglobulin E between the patients with different levels of adherence. In patients with adult-onset asthma, adherence to ICS was moderate. Poorer adherence (<80%) to ICS was associated with more rapid decline in lung function but was not associated to symptoms or markers of inflammatory endotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.