Evidence map›Paper›PMID 32211347›Full record

ArticleFrontiers in cellular and infection microbiology2020

Asymptomatic Bacterial Vaginosis Is Associated With Depletion of Mature Superficial Cells Shed From the Vaginal Epithelium.

D Elizabeth O'Hanlon, Pawel Gajer, Rebecca M Brotman, Jacques Ravel

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05701722 (Effects of Flourish HEC Vaginal Care System on Vaginal Microbiome in Women With Recurrent Bacterial Vaginosis), which is not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05701722 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of Flourish HEC Vaginal Care System on Vaginal Microbiome in Women With Recurrent Bacterial Vaginosis

TypeinterventionalSponsorVaginal Biome ScienceRan2023 to 2024Enrolled7ConditionsBacterial VaginosisArmsFlourish HEC Vaginal Care System
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Spatial organization ofInfection and immunity · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Hallmarks of Bacterial Vaginosis.Diagnostics (Basel, Switzerland) · 2025
    Review
  10. Article
  11. Article
  12. A New Phenotype inmBio · 2023
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

D Elizabeth O'HanlonInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, United States.
Pawel GajerInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, United States.
Rebecca M BrotmanInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, United States.
Jacques RavelInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, United States.
University of Maryland, Baltimore · US

Funding

Serologic Biomarkers of Human Sexually Transmitted Infection and DiseaseU19AI084044 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RAVEL, JACQUES · 2009 to 2018
$22.8M
Lubricant Use and the Vaginal MicrobiomeR01AI119012 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BROTMAN, REBECCA M. · 2016 to 2020
$3.7M
Elucidating causes of vaginal symptoms using a multi-omics approach - Admin. SupplementR01NR015495 · NINR · UNIVERSITY OF MARYLAND BALTIMORE · PI FORNEY, LARRY J, RAVEL, JACQUES · 2016 to 2020
$2.6M
The Microbial Ecology of Bacterial Vaginosis: A Fine Scale Resolution MetagenomicUH2AI083264 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RAVEL, JACQUES · 2009 to 2011
$1.9M
NIAID NIH HHS R01 AI119012NIAID NIH HHS U19 AI084044NIAID NIH HHS UH2 AI083264NINR NIH HHS R01 NR015495
6 · The paper itself

Abstract

Previous studies have described bacterial vaginosis (BV) as associated with increased cell-shedding from the cervicovaginal epithelium. Cell-shedding in excess of cell-proliferation is thought to decrease epithelial barrier function and increase susceptibility to infection. This study evaluated the number of shed cells in mid-vaginal smears from women with a diagnosis of symptomatic BV (sBV,

Indexed as

MicrobiotaVaginosis, BacterialEpitheliumFemaleHumansLactobacillusVaginaBVgynecologyvaginal microbiomevaginal microbiotawomen's health

Identifiers

PMID32211347
PMCPMC7076050
OpenAlexW3010324698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.