Evidence map›Paper›PMID 32211335›Full record

ReviewFrontiers in oncology2020

Glucose Metabolism on Tumor Plasticity, Diagnosis, and Treatment.

Xiaoping Lin, Zizheng Xiao, Tao Chen, Steven H Liang, Huiqin Guo

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed
7.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 173 citations in OpenAlex.

  1. Review
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  3. Article
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  5. Lifestyle-Based Approaches to Cancer Prevention and Treatment: Diet, Physical Activity, and Integrative Strategies.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Review
  6. Article
  7. Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle-tumor metabolic competition.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Article
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  10. Review
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  17. Review
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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Xiaoping LinDepartment of Nuclear Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Zizheng XiaoDepartment of Nuclear Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Tao ChenDepartment of Nuclear Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Steven H LiangDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
Huiqin GuoDepartment of Thoracic Surgery, Beijing Sijitan Hospital, Capital Medical University, Beijing, China.
Sun Yat-sen University Cancer Center · CNCapital Medical University · CNHarvard University · USSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant cells support tumor proliferation and progression by adopting to metabolic changes. Tumor cells altered metabolism by increasing glucose uptake and fermentation of glucose to lactate, even in the aerobic state and the presence of functioning mitochondria. Glucose metabolism in tumor plasticity has attracted great interests by clinicians and scientists in the past decades. This review discusses the previous and emerging researches on the tumor plasticity altered by changing glucose metabolism in different cancer cells, including cancer stem cells (CSCs). In addition, we summarize the rising applications of glucose metabolism in tumor diagnosis and treatment. Our objective is to direct future investigation on this altered metabolic phenotype and its application in patient care.

Indexed as

diagnosisglucosemetabolismplasticitytreatmenttumorWarburg effect

Identifiers

PMID32211335
PMCPMC7069415
OpenAlexW3009367721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.