ReviewCardiology research and practice2020
The Brain-Heart Connection in Takotsubo Syndrome: The Central Nervous System, Sympathetic Nervous System, and Catecholamine Overload.
Review in Cardiology research and practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
- Low-Grade Endotoxemia Is Associated with NOX2-Mediated Oxidative Stress and Endothelial Dysfunction in Takotsubo Syndrome: A Cross-Sectional Study.Antioxidants (Basel, Switzerland) · 2026Article
- Article
- Recalibrating stress regulation through mindfulness: a framework for adapting interventions for ACE-affected populations.Frontiers in psychology · 2026Article
- Takotsubo Syndrome in 2025: Evolving Concepts in Pathophysiology, Diagnosis, and Long-Term Management.Journal of clinical medicine · 2025Review
- Takotsubo syndrome: Unraveling the mystery behind its triggers (Review).International journal of molecular medicine · 2025Review
- Heart-Brain axis: is microvascular dysfunction the link between stroke and Takotsubo syndrome?The international journal of cardiovascular imaging · 2025Review
- Neurogenic Stunned Myocardium: A Narrative Review of Cardiopulmonary Failure Related to Subarachnoidal Haemorrhage.Cureus · 2025Review
- Takotsubo Syndrome in the Setting of Pacemaker Implantation: Results From a Multicenter National Prospective Registry.Reviews in cardiovascular medicine · 2025Article
- Hepatic T1 Mapping in Takotsubo Syndrome: A Preliminary Imaging Insight into the Cardiohepatic Axis.Life (Basel, Switzerland) · 2025Article
- Psychosocial and clinical characteristics in Takotsubo syndrome.Biology of sex differences · 2025Article
- Early stroke detection through machine learning in the prehospital setting.Frontiers in cardiovascular medicine · 2025Article
- Clinical applications of artificial intelligence and machine learning in neurocardiology: a comprehensive review.Frontiers in cardiovascular medicine · 2025Review
- Takotsubo Syndrome and Gender Differences: Exploring Pathophysiological Mechanisms and Clinical Differences for a Personalized Approach in Patient Management.Journal of clinical medicine · 2024Review
- mTORC1 hyperactivation and resultant suppression of macroautophagy contribute to the induction of cardiomyocyte necroptosis by catecholamine surges.Physiological reports · 2024Article
- Sympathetic and parasympathetic central autonomic networks.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A Systematic Review of COVID-19 Vaccine-Induced Takotsubo Cardiomyopathy: A 2023 Update.Cureus · 2023Review
- Establishment and effect evaluation of a stress cardiomyopathy mouse model induced by different doses of isoprenaline.Experimental and therapeutic medicine · 2023Article
- Takotsubo Cardiomyopathy in the Setting of Hypertrophic Cardiomyopathy Following Pacemaker Implantation.Cureus · 2023Article
- The Heart Is at Risk: Understanding Stroke-Heart-Brain Interactions with Focus on Neurogenic Stress Cardiomyopathy-A Review.Journal of stroke · 2023Review
- Global reports of takotsubo (stress) cardiomyopathy following COVID-19 vaccination: A systematic review and meta-analysis.International journal of cardiology. Heart & vasculature · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Takotsubo syndrome (TTS), also known as stress cardiomyopathy, is a type of acute heart failure syndrome triggered by intense psychological or physiological stress. TTS typically manifests as acute chest pain, dyspnea or syncope that mimics an acute myocardial infarction but does not involve coronary artery obstruction. The current understanding of the pathogenesis of TTS suggests that sympathetic nervous system (SNS) activation plays a central role. Specifically, stress can activate the SNS and lead to the over-release of catecholamine, which have toxic effects on myocardial tissue when present at excessive levels. However, the brain changes associated with TTS and the connection between the brain and the heart in patients with this disease remain unclear. In recent years, several published reports have revealed the role of this brain-heart connection in the pathogenesis of TTS. This review summarizes recent studies regarding SNS activation, catecholamine overload, and the brain-heart connection in patients with TTS from both pathophysiological and mechanistic aspects.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.