Evidence map›Paper›PMID 32211069›Full record

ArticleEvolutionary applications2020

Evolution of antibiotic cross-resistance and collateral sensitivity in

Natalie Ann Lozano-Huntelman, Nina Singh, Alondra Valencia, Portia Mira, Maral Sakayan, Ian Boucher, Sharon Tang, Kelley Brennan, Crystal Gianvecchio, Sorel Fitz-Gibbon and 1 more

Abstract read
In one paragraph

Article in Evolutionary applications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Tripartite Loops Reverse Antibiotic Resistance.Molecular biology and evolution · 2025
    Article
  4. Article
  5. Article
  6. Survival, resistance, and fitness dynamics ofEvolution, medicine, and public health · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Alteration ofMicrobiology spectrum · 2023
    Article
  12. Article
  13. Article
  14. Effect of Antibiotic Exposure onInternational journal of molecular sciences · 2023
    Article
  15. Review
  16. Acquisition of Daptomycin Resistance byFrontiers in microbiology · 2022
    Article
  17. Antifungal Activity of a Medical-Grade Honey Formulation againstJournal of fungi (Basel, Switzerland) · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Natalie Ann Lozano-HuntelmanDepartment of Ecology and Evolutionary Biology University of California Los Angeles CA USA.ORCID https://orcid.org/0000-0001-8796-0001
Nina SinghDepartment of Ecology and Evolutionary Biology University of California Los Angeles CA USA.ORCID https://orcid.org/0000-0002-4623-2451
Alondra ValenciaDepartment of Ecology and Evolutionary Biology University of California Los Angeles CA USA.ORCID https://orcid.org/0000-0002-5800-160X
Portia MiraDepartment of Ecology and Evolutionary Biology University of California Los Angeles CA USA.
Maral SakayanDepartment of Ecology and Evolutionary Biology University of California Los Angeles CA USA.
Ian BoucherDepartment of Ecology and Evolutionary Biology University of California Los Angeles CA USA.
Sharon TangDepartment of Ecology and Evolutionary Biology University of California Los Angeles CA USA.
Kelley BrennanDepartment of Ecology and Evolutionary Biology University of California Los Angeles CA USA.
Crystal GianvecchioDepartment of Ecology and Evolutionary Biology University of California Los Angeles CA USA.
Sorel Fitz-GibbonDepartment of Molecular, Cell, Developmental Biology University of California Los Angeles CA USA.
Pamela YehDepartment of Ecology and Evolutionary Biology University of California Los Angeles CA USA.

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Systems in Integrative BiologyT32GM008185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHOU, TOM · 1987 to 2022
$4.6M
NCATS NIH HHS UL1 TR001881NIGMS NIH HHS T32 GM008185
6 · The paper itself

Abstract

In bacteria, evolution of resistance to one antibiotic is frequently associated with increased resistance (cross-resistance) or increased susceptibility (collateral sensitivity) to other antibiotics. Cross-resistance and collateral sensitivity are typically evaluated at the minimum inhibitory concentration (MIC). However, these susceptibility changes are not well characterized with respect to the mutant prevention concentration (MPC), the antibiotic concentration that prevents a single-step mutation from occurring. We measured the MIC and the MPC for

Indexed as

antibiotic resistanceantimicrobialbacterial evolutioncorrelated traitssusceptible

Identifiers

PMID32211069
PMCPMC7086048

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.