ArticleNeural plasticity2020
The Reorganization of Insular Subregions in Individuals with Below-Level Neuropathic Pain following Incomplete Spinal Cord Injury.
Article in Neural plasticity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain morphology changes after spinal cord injury: A voxel-based meta-analysis.Frontiers in neurology · 2022Pooled it
- Preliminary efficacy of cognitive multisensory rehabilitation for neuropathic pain in chronic spinal cord injury: a phase I randomized controlled trial.Scientific reports · 2026Trial
- The hijacked insula: A stratified model of affective touch modulation in chronic pain.Journal of neuropsychology · 2026Review
- Brain networks activated when aggravating baseline chronic pain of an individual with new daily persistent headache: a case study.BMC neurology · 2025Article
- Chronic spinal cord injury is associated with morphometric brain changes in functional networks beyond the sensorimotor system.Frontiers in neurology · 2025Article
- Re-examining the Mysterious Role of the Cerebellum in Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Abnormal brain spontaneous neural activity in neuromyelitis optica spectrum disorder with neuropathic pain.Frontiers in neurology · 2024Article
- Multimodal quantitative magnetic resonance imaging of the thalamus in tinnitus patients with different outcomes after sound therapy.CNS neuroscience & therapeutics · 2023Article
- Intrinsic brain connectivity alterations despite intact pain inhibition in subjects with neuropathic pain after spinal cord injury: a pilot study.Scientific reports · 2023Article
- Article
- Role of insula and its subregions in progression from recent onset to chronic idiopathic tinnitus.Brain communications · 2023Article
- A shift of brain network hub after spinal cord injury.Frontiers in molecular neuroscience · 2023Article
- Rethinking the Body in the Brain after Spinal Cord Injury.Journal of clinical medicine · 2022Article
- Supraspinal nociceptive networks in neuropathic pain after spinal cord injury.Human brain mapping · 2021Article
- Neocortical circuits in pain and pain relief.Nature reviews. Neuroscience · 2021Review
- Exploring the hypothetical role of cerebellar pain prediction errors in fibromyalgia-associated chronic pain.Frontiers in neurologyArticle
- Periaqueductal gray connectivity in spinal cord injury-induced neuropathic pain.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the reorganization of insular subregions in individuals suffering from neuropathic pain (NP) after incomplete spinal cord injury (ISCI) and further to disclose the underlying mechanism of NP. Method: The 3D high-resolution T1-weighted structural images and resting-state functional magnetic resonance imaging (rs-fMRI) of all individuals were obtained using a 3.0 Tesla MRI system. A comparative analysis of structure and function connectivity (FC) with insular subareas as seeds in 10 ISCI individuals with below-level NP (ISCI-P), 11 ISCI individuals without NP (ISCI-N), and 25 healthy controls (HCs) was conducted. Associations between the structural and functional alteration of insula subregions and visual analog scale (VAS) scores were analyzed using the Pearson correlation in SPSS 20. Results: Compared with ISCI-N patients, when the left posterior insula as the seed, ISCI-P showed increased FC in right cerebellum VIIb and cerebellum VIII, Brodmann 37 (BA 37). When the left ventral anterior insula as the seed, ISCI-P indicated enhanced FC in right BA18 compared with ISCI-N patients. These increased FCs positively correlated with VAS scores. Relative to HCs, ISCI-P presented increased FC in the left hippocampus when the left dorsal anterior insula was determined as the seed. There was no statistical difference in the volume of insula subregions among the three groups. Conclusion: Our study indicated that distinctive patterns of FC in each subregion of insula suggest that the insular subareas participate in the NP processing through different FC following ISCI. Further, insula subregions could serve as a therapeutic target for NP following ISCI.
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