Evidence map›Paper›PMID 32210923›Full record

ArticleFrontiers in microbiology2020

Loss of the Periplasmic Chaperone Skp and Mutations in the Efflux Pump AcrAB-TolC Play a Role in Acquired Resistance to Antimicrobial Peptides in

Gal Kapach, Reut Nuri, Christiane Schmidt, Adi Danin, Shir Ferrera, Alon Savidor, Roman G Gerlach, Yechiel Shai

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Comparison of Phenotype and Genotype Virulence and Antimicrobial Factors ofInternational journal of molecular sciences · 2023
    Article
  5. Review
  6. Article
  7. Review
  8. Antimicrobial Peptides against Multidrug-ResistantJournal of medicinal chemistry · 2022
    Article
  9. Article
  10. Review
  11. Better together-Gut microbes
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Gal KapachDepartmant of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Reut NuriDepartmant of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Christiane SchmidtProject Group 5, Robert Koch Institute, Wernigerode, Germany.
Adi DaninDepartmant of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Shir FerreraDepartmant of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Alon Savidorde Botton Institute for Protein Profiling, The Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel.
Roman G GerlachProject Group 5, Robert Koch Institute, Wernigerode, Germany.
Yechiel ShaiDepartmant of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Weizmann Institute of Science · ILRobert Koch Institute · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial resistance to antibiotics is a major concern worldwide, leading to an extensive search for alternative drugs. Promising candidates are antimicrobial peptides (AMPs), innate immunity molecules, shown to be highly efficient against multidrug resistant bacteria. Therefore, it is essential to study bacterial resistance mechanisms against them. For that purpose, we used experimental evolution, and isolated a

Indexed as

AcrAB-TolCantimicrobial peptide (AMPs)bacterial resistanceefflux pumpperiplasmramRSkp

Identifiers

PMID32210923
PMCPMC7075815
OpenAlexW3011456554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.