ArticleFrontiers in psychiatry2020
Damaged Insula Network Contributes to Depression in Parkinson's Disease.
Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Bilateral intermittent theta burst stimulation over the primary motor cortex improves motor and affective symptoms via thalamic network reintegration in mid-stage Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Trial
- Functional Connectivity Changes Associated With Depression in Dementia With Lewy Bodies.International journal of geriatric psychiatry · 2025Trial
- Resting-State Functional MRI Approaches to Parkinsonisms and Related Dementia.Current neurology and neuroscience reports · 2024Review
- Insular dysfunction of interoception in major depressive disorder: from the perspective of neuroimaging.Frontiers in psychiatry · 2023Review
- Aberrant inter-network functional connectivity in drug-naive Parkinson's disease patients with tremor dominant and postural instability and gait difficulty.Frontiers in human neuroscience · 2023Article
- Enhanced brain functional connectivity and activation after 12-week Tai Chi-based action observation training in patients with Parkinson's disease.Frontiers in aging neuroscience · 2023Article
- The pathobiological basis of depression in Parkinson disease: challenges and outlooks.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Abnormal cortical atrophy and functional connectivity are associated with depression in Parkinson's disease.Frontiers in aging neuroscience · 2022Article
- Altered Neural Network Connectivity Predicts Depression inFrontiers in neuroscience · 2022Article
- Increasing of Blood Brain Barrier Permeability and the Association With Depression and Anxiety in Systemic Lupus Erythematosus Patients.Frontiers in medicine · 2022Article
- Machine Learning Models for Diagnosis of Parkinson's Disease Using Multiple Structural Magnetic Resonance Imaging Features.Frontiers in aging neuroscience · 2022Article
- Structural network topology and microstructural alterations of the anterior insula associate with cognitive and affective impairment in Parkinson's disease.Scientific reports · 2021Article
- Aberrant functional connectivity and activity in Parkinson's disease and comorbidity with depression based on radiomic analysis.Brain and behavior · 2021Article
- COVID-19 Pandemic and Psychiatric Symptoms: The Impact on Parkinson's Disease in the Elderly.Frontiers in psychiatry · 2020Article
- Networks Are Associated With Depression in Patients With Parkinson's Disease: A Resting-State Imaging Study.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepression is common in patients with Parkinson's disease (PD). Our previous studies suggest that depressed PD patients have altered insula structures. It is, however, still unknown whether the altered structures cause disruption of insula functional networks, further contributing to depression in PD.
methodsIn the present study, 17 depressed PD patients, 17 non-depressed PD patients, and 17 normal controls were enrolled. All subjects went through neurological and psychiatric clinical assessments. Resting-state functional magnetic resonance imaging and seed-based insula functional analyses were performed to examine the insula functional connectivity alterations in PD patients.
resultsWe found that compared with normal controls, PD patients exhibited significantly decreased insula functional connectivity widely across the whole brain. Compared with non-depressed PD patients, depressed patients showed further decreased functional connectivity in the middle frontal gyrus and inferior parietal lobe. Furthermore, connectivity between the left anterior insula and middle frontal gyrus was positively correlated with the cognitive scale score.
conclusionThese results suggest that insula networks were severely damaged in PD patients, and that the disrupted connection between the salience network and executive control network might contribute to depression in PD.
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