Evidence map›Paper›PMID 32210792›Full record

ArticleFrontiers in aging neuroscience2020

Development of Brain Structural Networks Over Age 8: A Preliminary Study Based on Diffusion Weighted Imaging.

Zhanxiong Wu, Yun Peng, Sudhakar Selvaraj, Paul E Schulz, Yingchun Zhang

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhanxiong WuSchool of Electronic Information, Hangzhou Dianzi University, Hangzhou, China.
Yun PengDepartment of Biomedical Engineering, University of Houston, Houston, TX, United States.
Sudhakar SelvarajLouis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The McGovern Medical School of UT Health Houston, Houston, TX, United States.
Paul E SchulzDepartment of Neurology, The McGovern Medical School of UT Health Houston, Houston, TX, United States.
Yingchun ZhangDepartment of Biomedical Engineering, University of Houston, Houston, TX, United States.

Funding

Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7M
MORPHOMETRY BIOMEDICAL INFORMATICS RESEARCH NETWORKU24RR021382 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2004 to 2008
$24.1M
STRUCTURE, FUNCTION AND COGNITION IN SCHIZOPHRENIAP50MH071616 · NIMH · WASHINGTON UNIVERSITY · PI BARCH, DEANNA · 2004 to 2008
$11.2M
NEUROMORPHOMETRY IN SCHIZOPHRENIA BY COMPUTER ALGORITHMR01MH056584 · NIMH · WASHINGTON UNIVERSITY · PI CSERNANSKY, JOHN G · 1998 to 2011
$4.2M
Functional-anatomic exploration of cognitive controlR01AG021910 · NIA · WASHINGTON UNIVERSITY · PI BUCKNER, RANDY L · 2005 to 2009
$1.2M
NCRR NIH HHS U24 RR021382NIA NIH HHS P01 AG003991NIA NIH HHS P30 AG066444NIA NIH HHS P50 AG005681NIA NIH HHS R01 AG021910NIMH NIH HHS P50 MH071616NIMH NIH HHS R01 MH056584NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

Brain structural network changes provide key information about the aging process of the brain. Unfortunately, there has yet to be a detailed characterization of these structural networks across different age groups. Efforts to classify these networks have also been hampered by their reliance on technically limited traditional methods, which are unable to track multiple fiber orientations within a voxel and consequently are prone to false detection and artifacts. In this study, a newly developed Ensemble Average Propagator (EAP) based probabilistic tractography method was applied to construct a structural network, with the strength of the link between any two brain functional regions estimated according to the alignment of the EAP along connecting pathways. Age-related changes in the topological organization of human brain structural networks were thereby characterized across a broad age range (ages 8-75 years). The data from 48 healthy participants were divided into four age groups (Group 1 aged 8-15 years; Group 2 aged 25-35 years; Group 3 aged 45-55 years; and, Group 4 aged 65-75 years;

Indexed as

brain developmentdiffusion weighted imagingensemble average propagatormagnetic resonance imagingstructural network

Identifiers

PMID32210792
PMCPMC7076118

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.