ArticleFrontiers in aging neuroscience2020
Loss of Sensitivity to Rewards by Dopamine Neurons May Underlie Age-Related Increased Probability Discounting.
Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Aging reduces motivation through decreased Bdnf expression in the ventral tegmental area.Molecular psychiatry · 2026Article
- Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Phenotypic characterization of an Atp13a2 knockout rat model of Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Aged mice exhibit faster acquisition of intravenous opioid self-administration with variable effects on intake.Neuropharmacology · 2025Article
- Aged mice exhibit faster acquisition of intravenous opioid self-administration with variable effects on intake.bioRxiv : the preprint server for biology · 2024Article
- Cognitive performance in aged rats is associated with differences in distinctive neuronal populations in the ventral tegmental area and altered synaptic plasticity in the hippocampus.Frontiers in aging neuroscience · 2024Article
- Age-related changes in basal forebrain afferent activation in response to food paired stimuli.Neuroscience letters · 2023Article
- Age-Related Changes in Risky Decision Making and Associated Neural Circuitry in a Rat Model.eNeuro · 2023Article
- Still Wanting to Win: Reward System Stability in Healthy Aging.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Normative aging is known to affect how decisions are made in risky situations. Although important individual variability exists, on average, aging is accompanied by greater risk aversion. Here the behavioral and neural mechanisms of greater risk aversion were examined in young and old rats trained on an instrumental probability discounting task. Consistent with the literature, old rats showed greater discounting of reward value when the probability of obtaining rewards dropped below 100%. Behaviorally, reward magnitude discrimination was the same between young and old rats, and yet these same rats exhibited reduced sensitivity to positive, but not negative, choice outcomes. The latter behavioral result was congruent with additional findings that the aged ventral tegmental neurons (including dopamine cells) were less responsive to rewards when compared to the same cell types recorded from young animals. In sum, it appears that reduced responses of dopamine neurons to rewards contribute to aging-related changes in risky decisions.
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Registered trials
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