Evidence map›Paper›PMID 32210724›Full record

ArticleInternational journal of biological sciences2020

Inhibition of Autophagy Signaling via 3-methyladenine Rescued Nicotine-Mediated Cardiac Pathological Effects and Heart Dysfunctions.

Peng Zhang, Yong Li, Yingjie Fu, Lei Huang, Bailin Liu, Lubo Zhang, Xuesi M Shao, Daliao Xiao

Open access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Peng ZhangLawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, USA.
Yong LiLawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, USA.
Yingjie FuLawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, USA.
Lei HuangLawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, USA.
Bailin LiuLawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, USA.
Lubo ZhangLawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, USA.
Xuesi M ShaoDepartment of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, California, USA.
Daliao XiaoLawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, California, USA.
Loma Linda University · USChongqing Medical University · CNUniversity of California, Los Angeles · US

Funding

Uterine Vascular Adaptation to Pregnancy and Chronic HypoxiaP01HD083132 · NICHD · LOMA LINDA UNIVERSITY · PI DUCSAY, CHARLES A · 2016 to 2020
$6.3M
Gestational Hypoxia and Programming of Maternal, Fetal and Newborn Vascular FunctionR01HL149608 · NHLBI · LOMA LINDA UNIVERSITY · PI PEARCE, WILLIAM J., WILSON, SEAN M · 2020 to 2023
$3.1M
Maternal inhaled nicotine leads to aberrant development of hypertensive phenotypeR01HL135623 · NHLBI · LOMA LINDA UNIVERSITY · PI SHAO, XUESI MAX, XIAO, DALIAO · 2017 to 2021
$2.3M
miRNA as a novel therapeutic target in antenatal nicotine-induced ischemic heartR01HD088039 · NICHD · LOMA LINDA UNIVERSITY · PI XIAO, DALIAO · 2017 to 2021
$1.6M
Developing an efficient E-cigarette aerosol generation and exposure system for rodent models with aerosol characteristics equivalent to those inhaled by E-cigarette usersR42DA044788 · NIDA · AUTOMATE SCIENTIFIC, INC. · PI KEWEKORDES, JOSEF, SHAO, XUESI MAX · 2019 to 2020
$884k
Nicotine-mediated fetal programming of vascular dysfunction phenotypeR03DA041492 · NIDA · LOMA LINDA UNIVERSITY · PI XIAO, DALIAO · 2017 to 2018
$158k
NHLBI NIH HHS R01 HL135623NHLBI NIH HHS R01 HL149608NICHD NIH HHS P01 HD083132NICHD NIH HHS R01 HD088039NIDA NIH HHS R03 DA041492NIDA NIH HHS R42 DA044788
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdenineAnimalsAutophagyBiomarkersEchocardiographyGlycogen Synthase Kinase 3 betaHeartMaleNicotineOxidative StressPhenotypePrecision MedicineRatsRats, Sprague-DawleyReactive Oxygen SpeciesReperfusion Injury3-methyladenineAdenineBiomarkersGlycogen Synthase Kinase 3 betaGsk3b protein, ratNicotineReactive Oxygen Speciesautophagy pathwaycardiac ischemia/reperfusion injurynicotine

Identifiers

PMID32210724
PMCPMC7085229
OpenAlexW3012816946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.