Evidence map›Paper›PMID 32210708›Full record

ArticleInternational journal of medical sciences2020

Downregulation of Long Noncoding RNA MIAT in the Retina of Diabetic Rats with Tail-vein Injection of Human Umbilical-cord Mesenchymal Stem Cells.

Chuan Yu, Kun Yang, Xuxia Meng, Bowen Cao, Fenglei Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
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  9. Non-coding RNA research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Chuan YuOphthalmology, Affiliated Hospital of Qingdao University, Qingdao 266500, Shandong Province, China.
Kun YangCentral Laboratory, Affiliated Hospital of Qingdao University, Qingdao 266500, Shandong Province, China.
Xuxia MengOphthalmology, Affiliated Hospital of Qingdao University, Qingdao 266500, Shandong Province, China.
Bowen CaoCenter for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, 72076, Tuebingen, Germany.
Fenglei WangOphthalmology, Affiliated Hospital of Qingdao University, Qingdao 266500, Shandong Province, China.
Qingdao University · CNSTZ eyetrial · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic retinopathy (DR) is the common and important cause for visual impairment and blindness in working-aged people. Microangiopathy and inflammatory reactions are the key components of DR. Recently, long non-coding RNA myocardial infarction-associated transcript (MIAT) has emerged as a vital player in regulation for inflammatory processes and microvascular dysfunction. Additionally, cell-based therapy provides a potential option for the treatment of DR. The anti-inflammatory effects and repair therapy of mesenchymal stem cells (MSCs) have been paid more attention. This study investigated the effects of human umbilical-cord mesenchymal stem cells (HUMSCs) injection on diabetic rat model. The results show that the level of MIAT is significantly decreased in the diabetic retina after the injection of HUMSCs. Moreover, HUMSCs can significantly decrease the expression of IL-1β and IL-6 mRNA; alleviate microvascular permeability, and upregulate Occludin expression. Studies have shown that MIAT knockdown could alleviate diabetes-induced inflammation responses and vascular leakage. Furthermore, our findings also showed that the expression of MIAT was positively correlated with the expression of IL-1β and IL-6. These results suggest that MIAT might play important regulatory roles in alleviating inflammatory reactions and microangiopathy inducing by DR after transplantation of HUMSCs.

Indexed as

Mesenchymal Stem Cell TransplantationAnimalsCapillary PermeabilityDiabetes Mellitus, ExperimentalDiabetic RetinopathyInterleukin-1betaInterleukin-6MaleOccludinRandom AllocationRats, Sprague-DawleyRetinaRNA, Long NoncodingIL1B protein, ratIl6 protein, ratInterleukin-1betaInterleukin-6Miat long non-coding RNAOccludinOcln protein, ratRNA, Long NoncodingDiabetic retinopathyHuman umbilical-cord mesenchymal stem cellsInflammationLong noncoding RNA MIATMicroangiopathy

Identifiers

PMID32210708
PMCPMC7085208
OpenAlexW3006706038

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.