Evidence map›Paper›PMID 32210707›Full record

ArticleInternational journal of medical sciences2020

Confocal Raman Spectral Imaging Study of DAPT, a γ-secretase Inhibitor, Induced Physiological and Biochemical Reponses in Osteosarcoma Cells.

Jie Li, Rui Wang, Jie Qin, Haishan Zeng, Kaige Wang, Qingli He, Difan Wang, Shuang Wang

Open access · goldAbstract read
In one paragraph

Article in International journal of medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. NOTCH Signaling in Osteosarcoma.Current issues in molecular biology · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jie LiInstitute of Photonics and Photon-Technology, Northwest University, Xi'an, Shaanxi 710069, China.
Rui WangDepartment of Orthopedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China.
Jie QinDepartment of Orthopedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China.
Haishan ZengImaging Unit - Integrative Oncology Department, BC Cancer Research Center, Vancouver, BC, V5Z1L3, Canada.
Kaige WangInstitute of Photonics and Photon-Technology, Northwest University, Xi'an, Shaanxi 710069, China.
Qingli HeDepartment of Physics, Northwest University, Xi'an, Shaanxi 710069, China.
Difan WangSchool of Life, Xidian University, Xi'an, Shaanxi 710071, China.
Shuang WangInstitute of Photonics and Photon-Technology, Northwest University, Xi'an, Shaanxi 710069, China.
Northwest University · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CNXidian University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Confocal Raman microspectral imaging was adopted to elucidate the cellular drug responses of osteosarcoma cells (OC) to N-[N-(3, 5-difluorophenyl acetyl)-L-alanyl]-sphenylglycine butyl ester (DAPT), a γ-secretase inhibitor, by identifying the drug induced subcellular compositional and structural changes.

Indexed as

Amyloid Precursor Protein SecretasesAnimalsCell Line, TumorCellular StructuresDipeptidesDrug Screening Assays, AntitumorMiceOsteosarcomaPrincipal Component AnalysisSpectrum Analysis, RamanAmyloid Precursor Protein SecretasesDipeptidesN-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl esterCellular HeterogeneityConfocal Raman microspectral imagingDAPTDrug ResponsesOsteosarcoma cells

Identifiers

PMID32210707
PMCPMC7085205
OpenAlexW3006451289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.