ArticleClinical epidemiology2020
Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973-2016.
Article in Clinical epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 86 citations in OpenAlex.
- Health outcomes following caesarean birth- An observational study of twins discordant for mode of delivery.European journal of obstetrics & gynecology and reproductive biology: X · 2026Article
- Mother-to-offspring microbial vertical transmission: timing, determinants, and impact on offspring susceptibility to gastrointestinal diseases.Medical review (2021) · 2026Review
- Plant-derived bioactives in early-life complementary foods: a nutritional blueprint for lifelong health.Journal of advanced research · 2026Review
- Gastrointestinal consequences of cesarean section birth: A systematic review of short- and long-term effects in infancy and beyond.World journal of clinical pediatrics · 2026Article
- Maternal gut microbial legacy shapes intestinal health and susceptibility of offspring to colitis.NPJ biofilms and microbiomes · 2026Article
- Genetically Modified Microorganisms: Risks and Regulatory Considerations for Human and Environmental Health.Microorganisms · 2026Review
- Review
- Mode of birth and risk of inflammatory bowel disease in offspring: an updated systematic review and meta-analysis.Frontiers in reproductive health · 2026Review
- Gut microbiota development across the lifespan: Disease links and health-promoting interventions.Journal of internal medicine · 2025Review
- Review
- Health outcomes up to 5 years in children born as a second child after a previous caesarean section in a first pregnancy: a Swedish population-based register study between 1999 and 2015.BMJ paediatrics open · 2025Article
- CRAmed: a conditional randomization test for high-dimensional mediation analysis in sparse microbiome data.Bioinformatics (Oxford, England) · 2025Article
- Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis.Ibrain · 2025Review
- Fertility in young-onset colorectal patients with cancer: a review.The oncologist · 2024Review
- Impacts of Different Perinatal Factors on Faecal Immune Compounds in Infants: Determination of Normal Values.International journal of molecular sciences · 2024Article
- Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis.Immunological reviews · 2024Review
- Prevalence of delivery mode in an Italian nationwide cohort with celiac disease: a SIGENP multicenter retrospective study (the CD-deliver-IT).Italian journal of pediatrics · 2024Article
- N6-methyladenosine in myeloid cells: a novel regulatory factor for inflammation-related diseases.Journal of physiology and biochemistry · 2024Review
- Global Burden of Inflammatory Bowel Disease Among Children and Adolescents: A Comprehensive Analysis (1990-2019).International journal of public health · 2024Article
- Immature neutrophils in cord blood exert increased expression of genes associated with antimicrobial function.Frontiers in immunology · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic inflammatory diseases in childhood and early adult life share aetiological factors operating from birth and onwards. In this study, we use data from the national Danish health registers to evaluate the risk of developing four common, immune-mediated hospital-diagnosed childhood chronic inflammatory diseases.
methodsA national population-based registry study. Data from the Danish Medical Birth Registry and the Danish National Patient Registry from January 1973 to March 2016 were linked at a personal level to evaluate any potential associations between caesarean section and development of Inflammatory bowel diseases, rheumatoid arthritis, coeliac disease and diabetes mellitus among the offspring. A model adjusted for parental age at birth, decade of birth, gender of child, and parents' chronic inflammatory disease status was used.
resultsThis register-based national cohort study of 2672708 children with information on delivery mode found an increased risk of diabetes, arthritis, coeliac disease, and inflammatory bowel disease for both girls and boys after caesarean section compared with vaginal delivery. The higher risk was present at least 40 years after delivery. In a subgroup analysis, both acute and elective caesarean section was associated with an increased risk of developing a chronic inflammatory disease.
conclusionsBeing born by caesarean section leads to increased host susceptibility for chronic inflammatory diseases that last for decades. This finding should be further addressed in future studies with the aim to support the development of new strategies for prevention, treatment, and maybe even cure.
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