ArticleInfection and drug resistance2020
Palmatine Is a Plasmid-Mediated Quinolone Resistance (PMQR) Inhibitor That Restores the Activity of Ciprofloxacin Against QnrS and AAC(6')-Ib-cr-Producing
Article in Infection and drug resistance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Progress in the application of traditional Chinese medicine and natural products for the prevention and treatment of calf diarrhea: a review.Frontiers in veterinary science · 2026Review
- Palmatine potentiates cefquinome efficacy against multidrug-resistantFrontiers in microbiology · 2025Article
- The comparison of the quality of selected brands of antibiotics in Tanzania sourced from different geographical regions.The Journal of antimicrobial chemotherapy · 2024Article
- Recent advances in nanoantibiotics against multidrug-resistant bacteria.Nanoscale advances · 2023Review
- First Report ofInternational journal of molecular sciences · 2023Article
- Palmatine Inhibits the Pathogenicity ofFoods (Basel, Switzerland) · 2022Article
- Biological Effects of Quinolones: A Family of Broad-Spectrum Antimicrobial Agents.Molecules (Basel, Switzerland) · 2021Review
- Occurrence and antimicrobial resistance ofFood science & nutrition · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe emergence of plasmid-mediated quinolone resistance (PMQR) is a global challenge in the treatment of clinical disease in both humans and animals and is exacerbated by the presence of different PMQR genes existing in the same bacterial strain. Here, we discovered that a natural isoquinoline alkaloid palmatine extracted from traditional Chinese medicinal plants effectively inhibited the activity of PMQR proteins QnrS and AAC(6')-Ib-cr.
methodsIn total 120 clinical ciprofloxacin-resistant
resultsPalmatine effectively restored the activity of ciprofloxacin against
conclusionOur findings suggest that palmatine is a potential efficacious compound to restore PMQR-mediated ciprofloxacin resistance and warrants further preclinical evaluations.
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