ArticlePloS one2020
Glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity in patients with diabetes mellitus type 2 infected with Epstein-Barr virus.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07768228 (The Effect of L-Carnitine on Wound Healing in Patients With Diabetic Foot Ulcer.), which is not on this map. Cited by 69 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of L-Carnitine on Wound Healing in Patients With Diabetic Foot Ulcer.
Who cites it
69 citing papers in PubMed, 3 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Clinical Evidence of Traditional Medicines in Modulating the Immune Response and Diabetic Wound Healing.Current topics in medicinal chemistry · 2026Pooled it
- Establishment and translational evaluation of animal models for skin wound healing: a systematic review.Frontiers in physiology · 2026Pooled it
- The Promising Role of Microbiome Therapy on Biomarkers of Inflammation and Oxidative Stress in Type 2 Diabetes: A Systematic and Narrative Review.Frontiers in nutrition · 2022Pooled it
- Putative Novel miR-1133 Is Associated with Oxidative Stress in Hyperglycemia-Induced Endothelial Cells.Biomedicines · 2026Article
- Multifunctional Janus Membrane Promotes Neurovascular Network Regeneration for Diabetic Wound Healing.Advanced healthcare materials · 2026Article
- The Effect ofFood science & nutrition · 2026Article
- Intelligent Biosensors for Diabetic Wound Monitoring.Biosensors · 2026Review
- Lung Vascular Remodeling and Oxidative Damage Induced by Chronic Intermittent Hypoxia.International journal of molecular sciences · 2026Article
- Mechanism of Liver Injury Induced by CrAnimals : an open access journal from MDPI · 2026Article
- Lipidomic and neurobehavioral alterations from developmental lead exposure in zebrafish.Journal of hazardous materials · 2026Article
- Metformin-Embedded Hydrogels: A Promising Approach for Accelerating Healing in Diabetic Ulcers.Current drug delivery · 2026Article
- Synergistic integration of exosomes and natural compounds in 3D-printed bioscaffolds: Revolutionizing diabetic wound healing through multifunctional therapeutic platforms.Iranian journal of basic medical sciences · 2026Review
- Role of oxidative stress in prediabetes development.Biochemistry and biophysics reports · 2025Review
- Oxidative Stress and Biomarkers in Craniofacial Fractures Healing: From Lipid Peroxidation to Antioxidant Therapies.Antioxidants (Basel, Switzerland) · 2025Review
- Progressive Hydrogel Applications in Diabetic Foot Ulcer Management: Phase-Dependent Healing Strategies.Polymers · 2025Review
- Hydrogel-Based Treatment of Diabetic Wounds: From Smart Responsive to Smart Monitoring.Gels (Basel, Switzerland) · 2025Review
- Therapeutic Applications and Mechanisms of Superoxide Dismutase (SOD) in Different Pathogenesis.Biomolecules · 2025Review
- Phosphocreatine Mitigates Doxorubicin-Induced Neurotoxicity in Rats by Regulating Mitochondrial Function and Apoptosis via the NF-κB/PGC-1α Pathway.Neuromolecular medicine · 2025Article
- AAT-MSC-EVs: Novel implications for suppressing ferroptosis, fibrosis and pain associated with chronic pancreatitis.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Oxidative stress markers and inflammation in type 1 and 2 diabetes are affected by BMI, treatment type, and complications.Scientific reports · 2025Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress is suggested to be the crucial factor in diabetes mellitus type 2 (DM2) pathogenesis and in the development of diabetic complications. Patients with DM2 may be more susceptible to infections due to hyperglycaemia-induced virulence of various microorganisms. Several studies pointed that Epstein-Barr virus (EBV) infection is associated with reactive oxygen species (ROS) production and/or activation of signalling pathways connected with ROS. The present study analyzed serum activity of glutathione peroxidase (GPx) and superoxide dismutase (SOD) in DM2 patients with and without EBV infection. Blood and saliva were collected from 120 patients with DM2. EBV DNA was detected in the saliva using nested-PCR technique. Spectrophotometric methods were implemented to determine serum GPx and SOD activity with the use of diagnostic kits produced by Randox Laboratories. GPx and SOD activity was decreased in diabetic patients, with the lowest values in DM2 EBV-positive patients. There was correlation between GPx and SOD activity-with increased value of GPx, SOD activity was also rised. In patients with DM2 history longer than 10 years as well as in DM2 patients with obesity, antioxidant enzymes activity was decreased. Determination of examined parameters may be useful in diabetic patients with EBV infection and could be important prognostic factor.
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