ArticleThe Journal of antibiotics2020
Inhibition of cellular inflammatory mediator production and amelioration of learning deficit in flies by deep sea Aspergillus-derived cyclopenin.
Article in The Journal of antibiotics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Metabolomic Profiling of Endophytic Fungi and the Host PlantPlants (Basel, Switzerland) · 2026Article
- Chartarlactams U-X: Novel Phenylspirodrimanes from a Marine Derived FungusMarine drugs · 2025Article
- Immunomodulatory Compounds from the Sea: From the Origins to a Modern Marine Pharmacopoeia.Marine drugs · 2024Review
- Anti-vibriosis bioactive molecules from Arctic Penicillium sp. Z2230.Bioresources and bioprocessing · 2023Article
- Bioactivity and Metabolome Mining of Deep-Sea Sediment-Derived Microorganisms Reveal New Hybrid PKS-NRPS Macrolactone fromMarine drugs · 2023Article
- Two New Alkaloids and a New Butenolide Derivative from the Beibu Gulf Sponge-Derived FungusMarine drugs · 2022Article
- Novel Sesquiterpene and Diterpene Aminoglycosides from the Deep-Sea-Sediment FungusMarine drugs · 2022Article
- Novel Harziane Diterpenes from Deep-Sea Sediment FungusMarine drugs · 2021Article
- A Treasure of Bioactive Compounds from the Deep Sea.Biomedicines · 2021Review
- Bioguided Isolation of Cyclopenin Analogues as Potential SARS-CoV-2 MBiomolecules · 2021Article
- Cellular Signal Transductions and Their Inhibitors Derived from Deep-Sea Organisms.Marine drugs · 2021Review
- Antimicrobial and Antioxidant Polyketides from a Deep-Sea-Derived FungusMarine drugs · 2020Article
- Isolation and Characterization of New Anti-Inflammatory and Antioxidant Components from Deep Marine-Derived FungusMarine drugs · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the course of screening lipopolysaccharide (LPS)-induced nitric oxide (NO) production inhibitors, two related benzodiazepine derivatives, cyclopenol and cyclopenin, were isolated from the extract of a deep marine-derived fungal strain, Aspergillus sp. SCSIOW2. Cyclopenol and cyclopenin inhibited the LPS-induced formation of NO and secretion of IL-6 in RAW264.7 cells at nontoxic concentrations. In terms of the mechanism underlying these effects, cyclopenol and cyclopenin were found to inhibit the upstream signal of NF-κB activation. These compounds also inhibited the expression of IL-1β, IL-6, and inducible nitric oxide synthase (iNOS) in mouse microglia cells, macrophages in the brain. In relation to the cause of Alzheimer's disease, amyloid-β-peptide is known to induce inflammation in the brain. Therefore, the present study investigated the ameliorative effects of these inhibitors on an in vivo Alzheimer's model using flies. Learning deficits were induced by the overexpression of amyloid-β42 in flies, and cyclopenin but not cyclopenol was found to rescue learning impairment. Therefore, novel anti-inflammatory activities of cyclopenin were identified, which may be useful as a candidate of anti-inflammatory agents for neurodegenerative diseases.
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