Evidence map›Paper›PMID 32210349›Full record

Trial reportScientific reports2020

Iron bioavailability from bouillon fortified with a novel ferric phytate compound: a stable iron isotope study in healthy women (part II).

Susanne Dold, Michael B Zimmermann, Frederike Jeroense, Christophe Zeder, Edwin Habeych, Nicola Galaffu, Dominik Grathwohl, Jasmin Tajeri Foman, Sylvie Merinat, Brigitte Rey and 2 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Susanne DoldETH Zurich, Laboratory of Human Nutrition, Zurich, Switzerland.
Michael B ZimmermannETH Zurich, Laboratory of Human Nutrition, Zurich, Switzerland.
Frederike JeroenseETH Zurich, Laboratory of Human Nutrition, Zurich, Switzerland.
Christophe ZederETH Zurich, Laboratory of Human Nutrition, Zurich, Switzerland.
Edwin HabeychNestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
Nicola GalaffuNestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
Dominik GrathwohlNestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
Jasmin Tajeri FomanNestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
Sylvie MerinatNestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
Brigitte ReyNestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
Magalie SabatierNestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
Diego MorettiETH Zurich, Laboratory of Human Nutrition, Zurich, Switzerland. diego.moretti@alumni.ethz.ch.ORCID http://orcid.org/0000-0002-7366-2182
Nestlé (Switzerland) · CHETH Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bouillon cubes are widely consumed and when fortified with iron could contribute in preventing iron deficiency. We report the development (part I) and evaluation (current part II) of a novel ferric phytate compound to be used as iron fortificant in condiments such as bouillon. Ferric pyrophosphate (FePP), is the compound of choice due to its high stability in foods, but has a modest absorption in humans. Our objective was to assess iron bioavailability from a novel iron fortificant consisting of ferric iron complexed with phytic acid and hydrolyzed corn protein (Fe-PA-HCP), used in bouillon with and without an inhibitory food matrix. In a randomised single blind, cross-over study, we measured iron absorption in healthy adult women (n = 22). In vitro iron bioaccessibility was assessed using a Caco-2 cell model. Iron absorption from Fe-PA-HCP was 1.5% and 4.1% in bouillon with and without inhibitory matrix, respectively. Relative iron bioavailability to FeSO

Indexed as

Food, FortifiedAdultCaco-2 CellsCross-Over StudiesFemaleFerric CompoundsFerritinsHumansHydrolysisIronIron RadioisotopesPhytic AcidPlant Proteins, DietarySingle-Blind MethodYoung AdultZea maysFerric CompoundsFerritinsIronIron-54Iron RadioisotopesPhytic AcidPlant Proteins, Dietary

Identifiers

PMID32210349
PMCPMC7093532
OpenAlexW3013496551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.