Evidence map›Paper›PMID 32210305›Full record

ArticleScientific reports2020

The Human Lung Glycome Reveals Novel Glycan Ligands for Influenza A Virus.

Nan Jia, Lauren Byrd-Leotis, Yasuyuki Matsumoto, Chao Gao, Alexander N Wein, Jenna L Lobby, Jacob E Kohlmeier, David A Steinhauer, Richard D Cummings

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 82 citations in OpenAlex.

  1. Review
  2. Glycan Fingerprint of Malignant Pleural Mesothelioma.International journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. IntegratingMolecular omics · 2025
    Article
  11. Article
  12. Expedient Assembly of MultiantennaryJournal of the American Chemical Society · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Chemoenzymatic Synthesis of Tri-antennary N-Glycans Terminating in Sialyl-LewisChemistry (Weinheim an der Bergstrasse, Germany) · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nan Jia *Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6317-269X
Lauren Byrd-Leotis *Beth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7984-0357
Yasuyuki MatsumotoBeth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.
Chao GaoBeth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA.
Alexander N WeinDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Jenna L LobbyDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Jacob E KohlmeierDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-7209-6641
David A SteinhauerDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA. dsteinh@emory.edu.ORCID http://orcid.org/0000-0001-8922-7524
Richard D CummingsBeth Israel Deaconess Medical Center, Department of Surgery and Harvard Medical School Center for Glycoscience, Harvard Medical School, Boston, MA, USA. rcummin1@bidmc.harvard.edu.ORCID http://orcid.org/0000-0002-8918-5034
Beth Israel Deaconess Medical Center · USEmory University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3M
Overall Priority Score P41GM103694 · NIGMS · EMORY UNIVERSITY · PI CUMMINGS, RICHARD D · 2013 to 2018
$6.9M
NIAID NIH HHS HHSN272201400004CNIGMS NIH HHS P41 GM103694NIGMS NIH HHS T32 GM008169
6 · The paper itself

Abstract

Glycans within human lungs are recognized by many pathogens such as influenza A virus (IAV), yet little is known about their structures. Here we present the first analysis of the N- and O- and glycosphingolipid-glycans from total human lungs, along with histological analyses of IAV binding. The N-glycome of human lung contains extremely large complex-type N-glycans with linear poly-N-acetyllactosamine (PL) [-3Galβ1-4GlcNAcβ1-]

Indexed as

Binding SitesHumansInfluenza A virusInfluenza, HumanLectinsLigandsLungNeuraminidasePhosphorylationPolysaccharidesSialic AcidsLectinsLigandsNeuraminidasePolysaccharidesSialic Acids

Identifiers

PMID32210305
PMCPMC7093477
OpenAlexW3012986636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.