Observational studyScientific reports2020
Retinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography.
Observational study in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Retinal Structural and Microvascular Findings on OCT and OCTA in Hemodialysis and Kidney Transplant Recipients and Their Association with Mineral Metabolism Parameters.Medical sciences (Basel, Switzerland) · 2026Article
- Optical Coherence Tomography and Optical Coherence Tomography-Angiography Chronic Changes in End-Stage Renal Disease: A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
- Early-stage diabetic retinopathy: gut-metabolic triggers, immune-neurodegeneration, and interventions.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Review
- Central retinal volume derived from optical coherence tomography as a potential predictor of mortality in the old-aged population- results from the German AugUR study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Retinal and choroidal blood flow changes in dialysis patients assessed by wide-field swept-source optical coherence tomography angiography.Frontiers in medicine · 2025Article
- A semantic segmentation method to analyze retinal vascular parameters of diabetic nephropathy.Frontiers in medicine · 2024Article
- Retinal nerve fiber layer defects and chronic kidney disease: the Kailuan Eye Study.International journal of ophthalmology · 2024Article
- Choroidal and retinal thinning in chronic kidney disease independently associate with eGFR decline and are modifiable with treatment.Nature communications · 2023Article
- Retinal Neurodegeneration and Visual Acuity Decline in Patients with Chronic Kidney Disease.Ophthalmology and therapy · 2023Article
- Association of chorioretinal thickness with chronic kidney disease.BMC ophthalmology · 2023Article
- Accelerated Peripapillary Retinal Nerve Fiber Layer Degeneration in Patients With Chronic Kidney Disease: A 2-Year Longitudinal Study.Translational vision science & technology · 2022Article
- Stereotactic radiosurgery for orbital cavernous venous malformation: a single center's experience for 15 years.Acta neurochirurgica · 2021Article
- Retinal Neurovascular Impairment in Non-diabetic and Non-dialytic Chronic Kidney Disease Patients.Frontiers in neuroscience · 2021Article
- Associations between Chronic Kidney Disease and Thinning of Neuroretinal Layers in Multiethnic Asian and White Populations.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spectral-domain optical coherence tomography (SD-OCT) represents a reliable tool for retinal layer volume and thickness measurement. The aim of this study was to evaluate retinal changes indicating neurodegenerative processes in patients with end-stage renal disease (ESRD) compared to healthy controls. This was a cross-sectional, single-center study comprising 32 ESRD patients and 38 controls. Sectoral retinal nerve fiber layer (RNFL) thickness and retinal layer volumes were obtained by SD-OCT. Age- and gender-adjusted retinal layer volumes such as total retinal volume (p = 0.037), ganglion cell layer volume (GCL, p = 0.003), ganglion cell layer - inner plexiform layer volume (GCL-IPL, p = 0.005) and inner retinal layer volume (IRL, p = 0.042) of the right eye were lower in ESRD patients. Inner plexiform layer volume of both eyes (IPL, right eye: p = 0.017; left eye: 0.044) was reduced, as was RNFL thickness in the temporal superior sector (right eye: p = 0.016). A subgroup analysis excluding patients with diabetes revealed that GCL (p = 0.014) and GCL-IPL volume of the right eye (p = 0.024) and temporal superior sector of the RNFL scan (p = 0.021) in ESRD patients were still significantly thinner. We observed a decrease in several retinal layer volumes and temporal RNFL thickness indicative of retinal neurodegenerative processes in patients with ESRD.
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