ArticleAntioxidants (Basel, Switzerland)2020
Effects of Melatonin Administration to Pregnant Ewes under Heat-Stress Conditions, in Redox Status and Reproductive Outcome.
Article in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Effect of Melatonin Supplementation on Reproductive Performance, Hormonal Profile and Antioxidant Status in Sheep Under Subtropical Conditions.Animals : an open access journal from MDPI · 2026Article
- Pregnancy-Associated Glycoproteins Identification in Skopelos Goat Milk by Means of Mass Spectrometry.Veterinary sciences · 2025Article
- The effect of melatonin implants on the embryo yield and oxidative stress levels in superovulated Holstein heifers.Veterinary research communications · 2025Article
- Prenatal melatonin reprograms liver injury in male pups caused by maternal exposure to a high-fat diet and microplastics.Apoptosis : an international journal on programmed cell death · 2025Article
- The Protective Effects of Melatonin on Hainan Black Goats Under Heat Stress: Understanding Its Actions and Mechanisms.Antioxidants (Basel, Switzerland) · 2025Article
- Effect of Heat Stress on Lactating and Non-Lactating Blackbelly Ewes under Tropical Conditions during Summer.Animals : an open access journal from MDPI · 2024Article
- Proteomics Analysis of Pregnancy in Ewes under Heat Stress Conditions and Melatonin Administration.Animals : an open access journal from MDPI · 2024Article
- Melatonin as a multifunctional modulator: emerging insights into its role in health, reproductive efficiency, and productive performance in livestock.Frontiers in physiology · 2024Review
- Melatonin Administration to Pregnant Ewes for Coccidiosis Control in Their Offspring.Animals : an open access journal from MDPI · 2023Article
- Melatonin Supplementation during the Late Gestational Stage Enhances Reproductive Performance of Sows by Regulating Fluid Shear Stress and Improving Placental Antioxidant Capacity.Antioxidants (Basel, Switzerland) · 2023Article
- Melatonin-Attenuated Oxidative Stress in High-Risk Pregnant Women Receiving Enoxaparin and Aspirin.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Redox Status and Hematological Variables in Melatonin-Treated Ewes during Early Pregnancy under Heat Stress.Veterinary sciences · 2022Article
- Effects of Implanting Exogenous Melatonin 40 Days before Lambing on Milk and Colostrum Quality.Animals : an open access journal from MDPI · 2022Article
- Melatonin Protects Tobacco Suspension Cells against Pb-Induced Mitochondrial Dysfunction.International journal of molecular sciences · 2021Article
- Association of Melatonin Administration in Pregnant Ewes with Growth, Redox Status and Immunity of Their Offspring.Animals : an open access journal from MDPI · 2021Article
- The Significance of Redox Biomarkers in the Evaluation of the Antioxidant Profile In Vitro and In Vivo.Antioxidants (Basel, Switzerland) · 2021Article
- Biofunctional Feed Supplemented With By-products of Olive Oil Production Improves Tissue Antioxidant Profile of Lambs.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat stress is a known promoter of reactive oxygen species generation, which may compromise pregnancy and foetal development. Melatonin is a pleiotropic molecule that regulates various processes including pregnancy. Thus, it could be used to ameliorate the redox status of pregnant heat-stressed ewes and the outcome of their pregnancy. Sixty-eight ewes participated in the study, which were allocated into two equal groups, i.e., Melatonin (M) and Control (C) group. All ewes were exposed to heat stress from D0 to D120. In both groups, after oestrus synchronization of ewes, rams were introduced to them for mating (D16). In M group, starting with sponges' insertion (D0), melatonin implants were administered four-fold every 40 days. Pregnancy diagnosis was performed by means of ultrasonography. Daily evaluation of temperature humidity index (THI), rectal temperature, and breathing rate were performed throughout the study. Blood samples were collected repeatedly from D0 until weaning for assaying redox biomarkers. Milk yield was measured thrice during puerperium. The results showed that melatonin administration throughout pregnancy improved the redox status of heat-stressed ewes and increased the mean number and bodyweight of lambs born per ewe, as well as the milk production. Therefore, melatonin may be used as antioxidant regimen in heat-stressed ewes for improving their reproductive traits.
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