ArticleMetabolites2020
Extensive Profiling of Polyphenols from two
Article in Metabolites, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- A Comprehensive Research Review of Herbal Textual Research, Phytochemistry, Pharmacology, Traditional Uses, Clinical Application, Safety Evaluation, and Quality Control ofPharmaceuticals (Basel, Switzerland) · 2024Review
- Identification of Key Factors in Cartilage Tissue During the Progression of Osteoarthritis Using a Non-targeted Metabolomics Strategy.Phenomics (Cham, Switzerland) · 2024Article
- Review
- Quality Assessment of Burdekin Plum (Molecules (Basel, Switzerland) · 2023Article
- Characterization and Evaluation of Antioxidant and Anti-Inflammatory Activities of Flavonoids from the Fruits ofFoods (Basel, Switzerland) · 2022Article
- Authentication of Geographical Origin in Hainan Partridge Tea (Foods (Basel, Switzerland) · 2021Article
- Systematic Discovery and Pathway Analyses of Metabolic Disturbance in COVID-19.Infectious diseases & immunity · 2021Article
- Special Issue: Plant Metabolomics.Metabolites · 2020Article
- A Novel Urease Inhibitor of Ruminal Microbiota Screened through Molecular Docking.International journal of molecular sciences · 2020Article
- Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis.Cell metabolism · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Various species of globeflowers, belonging to the genus Trollius, have been extensively used in traditional Chinese medicine due to their anti-inflammatory, antimicrobial, and antiviral properties, which are mainly attributed to their high polyphenol content. Differences in polyphenol composition, and abundances, will lead to varying treatment efficacies of globeflowers. Herein, we employ a combination of targeted and untargeted mass spectrometry (MS) approaches to characterize and quantify a comprehensive array of polyphenols, mainly including flavonoids and phenolic acids in two globeflower species commonly used in Chinese medicine, Trollius chinensis Bunge and Trollius ledebouri Reichb. In addition, free radical scavenging activity was investigated to evaluate the association between polyphenol composition and antioxidation capacity. Liquid chromatography (LC)-based separation and multiple-reaction-monitoring (MRM) transitions were optimized using a library of 78 polyphenol reference compounds to achieve absolute quantification on triple quadrupoles MS (QqQ). The analytical method was further expanded via high-resolution MS to provide relative quantitation of an additional 104 endogenous polyphenols in globeflowers not included in our reference library. Our results revealed stark differences in polyphenol content between T. chinensis and T. ledebouri, emphasizing the need for systematic characterization of polyphenol composition to ensure treatment efficacy and consistency in standardizing the use of globeflowers in Chinese medicine.
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