Evidence map›Paper›PMID 32210159›Full record

ArticleMarine drugs2020

Design, Synthesis and Biological Evaluation of Jahanyne Analogs as Cell Cycle Arrest Inducers.

Baijun Ye, Jianmiao Gong, Qiuying Li, Shiqi Bao, Xuemei Zhang, Jing Chen, Qing Meng, Bolin Chen, Peng Jiang, Liang Wang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Baijun YeThe State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China.
Jianmiao GongAccendatech Co., Ltd., Tianjin 300384, China.
Qiuying LiAccendatech Co., Ltd., Tianjin 300384, China.
Shiqi BaoAccendatech Co., Ltd., Tianjin 300384, China.
Xuemei ZhangAccendatech Co., Ltd., Tianjin 300384, China.
Jing ChenAccendatech Co., Ltd., Tianjin 300384, China.
Qing MengThe State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China.
Bolin ChenThe State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China.
Peng JiangThe State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China.
Liang WangThe State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China.
Yue ChenThe State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China.
Nankai University · CNState Key Laboratory of Medicinal Chemical Biology

Funding

Fundamental Research Funds for the Central Universities xxxxxNational Natural Science Foundation of China 81573282 and 81703350National Science Fund for Distinguished Young Scholars 81625021the Hundred Young Academic Leaders Program of Nankai University xxxxx
6 · The paper itself

Abstract

Jahanyne, a lipopeptide with a unique terminal alkynyl and OEP (2-(1-oxo-ethyl)-pyrrolidine) moiety, exhibits anticancer activity. We synthesized jahanyne and analogs modified at the OEP moiety, employing an α-fluoromethyl ketone (FMK) strategy. Preliminary bioassays indicated that compound

Indexed as

Drug DesignApoptosisAquatic OrganismsCell Line, TumorCell ProliferationCyanobacteriaDrug Screening Assays, AntitumorG1 Phase Cell Cycle CheckpointsHumansLipopeptidesLung NeoplasmsMolecular StructureStructure-Activity RelationshipjahanyneLipopeptidesG0/G1 phase arrestjahanynelipopeptideα-fluoromethyl ketone

Identifiers

PMID32210159
PMCPMC7142928
OpenAlexW3012705424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.