ArticlePharmaceutics2020
Mechanochemical Formation of Racemic Praziquantel Hemihydrate with Improved Biopharmaceutical Properties.
Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Stability of Ternary Drug-Drug-Drug Coamorphous Systems Obtained Through Mechanochemistry.Pharmaceutics · 2025Article
- Amorphous Solid Dispersion Formation for Enhanced Release Performance of Racemic and Enantiopure Praziquantel.Molecular pharmaceutics · 2024Article
- Mechanochemical Synthesis of New Praziquantel Cocrystals: Solid-State Characterization and Solubility.Crystal growth & design · 2024Article
- Praziquantel Fifty Years on: A Comprehensive Overview of Its Solid State.Pharmaceutics · 2023Review
- Co-Crystalline Solid Solution Affords a High-Soluble and Fast-Absorbing Form of Praziquantel.Molecular pharmaceutics · 2023Article
- Kinetics of Drug Release from Clay Using Enhanced Sampling Methods.Pharmaceutics · 2022Article
- Article
- In Vivo Evaluation of Praziquantel-Loaded Solid Lipid Nanoparticles againstInternational journal of molecular sciences · 2022Article
- Mechanochemical Synthesis and Physicochemical Characterization of Previously Unreported Praziquantel Solvates with 2-Pyrrolidone and Acetic Acid.Pharmaceutics · 2021Article
- Direct Powder Extrusion 3D Printing of Praziquantel to Overcome Neglected Disease Formulation Challenges in Paediatric Populations.Pharmaceutics · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Praziquantel (PZQ) is the first-line drug used against schistosomiasis, one of the most common parasitic diseases in the world. A series of crystalline structures including two new polymorphs of the pure drug and a series of cocrystals of PZQ have been discovered and deposited in the Cambridge Structural Database (CSD). This work adds to the list of multicomponent forms of PZQ a relevant example of a racemic hemihydrate (PZQ-HH), obtainable from commercial PZQ (polymorphic Form A) through mechanochemistry. Noteworthy, the formation of the new hemihydrate strongly depends on the initial polymorphic form of PZQ and on the experimental conditions used. The new PZQ-HH has been fully characterized by means of HPLC, Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), Hot-Stage Microscopy (SEM), Powder X-Ray Diffraction (PXRD), Scanning Electron Microscopy (SEM), FT-IR, polarimetry, solid-state NMR (SS-NMR), solubility and intrinsic dissolution rate (IDR), and
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.