Evidence map›Paper›PMID 32210102›Full record

ArticleInternational journal of molecular sciences2020

DNA Methylation in Neurodegenerative and Cerebrovascular Disorders.

Olaia Martínez-Iglesias, Iván Carrera, Juan Carlos Carril, Lucía Fernández-Novoa, Natalia Cacabelos, Ramón Cacabelos

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 67 citations in OpenAlex.

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  16. Novel therapeutic approaches to target neurodegeneration.British journal of pharmacology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Olaia Martínez-IglesiasEuroespes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Corunna, Spain.
Iván CarreraEuroespes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Corunna, Spain.
Juan Carlos CarrilEuroespes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Corunna, Spain.ORCID 0000-0002-3159-3545
Lucía Fernández-NovoaEuroespes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Corunna, Spain.
Natalia CacabelosEuroespes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Corunna, Spain.
Ramón CacabelosEuroespes Biomedical Research Center, International Center of Neuroscience and Genomic Medicine, 15165 Corunna, Spain.
EuroEspes Biomedical Research Center · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA methylation is an epigenetic mechanism by which methyl groups are added to DNA, playing a crucial role in gene expression regulation. The aim of the present study is to compare methylation status of healthy subjects with that of patients with Alzheimer's, Parkinson's or Cerebrovascular diseases. We also analyze methylation status of a transgenic Alzheimer's disease mouse model (3xTg-AD). Our results show that both global methylation (

Indexed as

DNA MethylationEpigenesis, GeneticAnimalsBiomarkersCerebrovascular DisordersDisease Models, AnimalDisease SusceptibilityGene Expression ProfilingGene Expression RegulationMiceMice, TransgenicNeurocognitive DisordersBiomarkersAlzheimer diseasecerebrovascular diseasesdiagnostic biomarkerDNA methylationDNMTsneurodegenerative diseasesParkinson disease

Identifiers

PMID32210102
PMCPMC7139499
OpenAlexW3012732993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.