Evidence map›Paper›PMID 32210081›Full record

ArticleInternational journal of molecular sciences2020

Calcineurin Controls Expression of EAAT1/GLAST in Mouse and Human Cultured Astrocytes through Dynamic Regulation of Protein Synthesis and Degradation.

Giulia Dematteis, Elena Restelli, Roberto Chiesa, Eleonora Aronica, Armando A Genazzani, Dmitry Lim, Laura Tapella

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Selenomethionine Attenuated HAntioxidants (Basel, Switzerland) · 2023
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Giulia DematteisDepartment of Pharmaceutical Sciences, Università del Piemonte Orientale "Amedeo Avogadro", 28100 Novara, Italy.
Elena RestelliDepartment of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milano, Italy.
Roberto ChiesaDepartment of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milano, Italy.ORCID 0000-0002-3842-3733
Eleonora AronicaAmsterdam UMC, University of Amsterdam, Department of (Neuro) Pathology, 1105 AZ Amsterdam, The Netherlands.
Armando A GenazzaniDepartment of Pharmaceutical Sciences, Università del Piemonte Orientale "Amedeo Avogadro", 28100 Novara, Italy.
Dmitry LimDepartment of Pharmaceutical Sciences, Università del Piemonte Orientale "Amedeo Avogadro", 28100 Novara, Italy.ORCID 0000-0002-4316-2654
Laura TapellaDepartment of Pharmaceutical Sciences, Università del Piemonte Orientale "Amedeo Avogadro", 28100 Novara, Italy.ORCID 0000-0002-8159-1628
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITMario Negri Institute for Pharmacological Research · ITAmsterdam University Medical Centers · NL

Funding

Fondazione Cariplo 2013-0795Fondazione Cariplo 2014-1094Fondazione CRT 1393-2017Università del Piemonte Orientale FAR-2016Università del Piemonte Orientale FAR-2019
6 · The paper itself

Abstract

Alterations in the expression of glutamate/aspartate transporter (GLAST) have been associated with several neuropathological conditions including Alzheimer's disease and epilepsy. However, the mechanisms by which GLAST expression is altered are poorly understood. Here we used a combination of pharmacological and genetic approaches coupled with quantitative PCR and Western blot to investigate the mechanism of the regulation of GLAST expression by a Ca

Indexed as

Gene Expression RegulationAnimalsAstrocytesCalcineurinCalcineurin InhibitorsCells, CulturedExcitatory Amino Acid Transporter 1Fluorescent Antibody TechniqueGene Knockout TechniquesHippocampusHumansMiceMice, KnockoutModels, MolecularProtein BiosynthesisProteolysisCalcineurinCalcineurin InhibitorsExcitatory Amino Acid Transporter 1SLC1A3 protein, humanastrocytescalcineurinGLASTprotein degradationprotein synthesisproteostasis

Identifiers

PMID32210081
PMCPMC7139922
OpenAlexW3011744093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.