Evidence map›Paper›PMID 32210079›Full record

ArticleInternational journal of molecular sciences2020

The IL-17A/IL-17RA Axis Is Not Related to Overall Survival and Cancer Stem Cell Modulation in Pancreatic Cancer.

Jiahui Li, Christopher Betzler, Philipp Lohneis, Marie Christine Popp, Jiwei Qin, Thomas Kalinski, Thomas Wartmann, Christiane J Bruns, Yue Zhao, Felix C Popp

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Modeling pancreatic cancer in mice for experimental therapeutics.Biochimica et biophysica acta. Reviews on cancer · 2021
    Review
  4. IL-17 in pancreatic disease: pathogenesis and pharmacotherapy.American journal of cancer research · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jiahui LiDepartment of General, Visceral, Tumor and Transplantation Surgery, University Hospital of Cologne, Kerpener Straße 62, 50937 Cologne, Germany.
Christopher BetzlerDepartment of General, Visceral, Tumor and Transplantation Surgery, University Hospital of Cologne, Kerpener Straße 62, 50937 Cologne, Germany.
Philipp LohneisInstitute of Pathology, University Hospital of Cologne, Kerpener Straße 62, 50937 Cologne, Germany.
Marie Christine PoppDepartment of General, Visceral, Tumor and Transplantation Surgery, University Hospital of Cologne, Kerpener Straße 62, 50937 Cologne, Germany.
Jiwei QinDepartment of General, Visceral und Vascular Surgery, Otto von Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.
Thomas KalinskiInstitute for Pathology, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.
Thomas WartmannDepartment of General, Visceral und Vascular Surgery, Otto von Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.
Christiane J BrunsDepartment of General, Visceral, Tumor and Transplantation Surgery, University Hospital of Cologne, Kerpener Straße 62, 50937 Cologne, Germany.
Yue ZhaoDepartment of General, Visceral, Tumor and Transplantation Surgery, University Hospital of Cologne, Kerpener Straße 62, 50937 Cologne, Germany.ORCID 0000-0002-6790-3402
Felix C PoppDepartment of General, Visceral, Tumor and Transplantation Surgery, University Hospital of Cologne, Kerpener Straße 62, 50937 Cologne, Germany.
University Hospital Cologne · DEOtto-von-Guericke-Universität Magdeburg · DE

Funding

China Scholarship Council CSCDeutsche Forschungsgemeinschaft BR1614.11-1
6 · The paper itself

Abstract

(1) Background: IL-17A accelerates pancreatic intraepithelial neoplasia (PanIN) progression. In this study, we examined whether IL-17A/IL-17RA promotes pancreatic ductal adenocarcinoma (PDAC) aggressiveness in terms of survival and cancer stem cell modulation. (2) Methods: In vitro, the wound-healing assay, the sphere formation assay, and flow cytometry were applied to assess cancer stem cell features. In vivo, pancreatic tumors were induced in C57BL/6 mice using electroporation with oncogenic plasmids (P53-/- R172H; KrasG12V). Anti-IL-17 antibodies were administered as immunotherapy. We analyzed IL-17A/IL-17RA related survival using publicly available transcriptomic data (

Indexed as

Signal TransductionAnimalsBiomarkersCarcinoma, Pancreatic DuctalCell Line, TumorDisease Models, AnimalDisease SusceptibilityHumansInterleukin-17MiceMolecular Targeted TherapyNeoplastic Stem CellsPancreatic NeoplasmsPrognosisReceptors, Interleukin-17Xenograft Model Antitumor AssaysBiomarkersIL17A protein, humanIL17RA protein, humanInterleukin-17Receptors, Interleukin-17cancer stem cellIL-17AIL-17RAimmunotherapypancreatic cancer

Identifiers

PMID32210079
PMCPMC7139783
OpenAlexW3012675442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.