Evidence map›Paper›PMID 32209985›Full record

ArticleInternational journal of molecular sciences2020

Origins of Alterations to

Andrea Gama, Jorge William Vargas-Franco, Diana Carolina Sánchez Mesa, Elizabeth Restrepo Bedoya, Jérome Amiaud, Sylvie Babajko, Ariane Berdal, Ana Carolina Acevedo, Dominique Heymann, Frédéric Lézot and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 4 countries.

Andrea GamaCentre de Recherche des Cordeliers, INSERM UMR-1138, Sorbonne Université, Université de Paris, Laboratoire de Physiopathologie Orale Moléculaire, F-75006 Paris, France.ORCID 0000-0002-7403-9720
Jorge William Vargas-FrancoINSERM, UMR-1238, Equipe 1, Faculté de Médecine, Université de Nantes, F-44035 Nantes, France.
Diana Carolina Sánchez MesaCentre de Recherche des Cordeliers, INSERM UMR-1138, Sorbonne Université, Université de Paris, Laboratoire de Physiopathologie Orale Moléculaire, F-75006 Paris, France.
Elizabeth Restrepo BedoyaCentre de Recherche des Cordeliers, INSERM UMR-1138, Sorbonne Université, Université de Paris, Laboratoire de Physiopathologie Orale Moléculaire, F-75006 Paris, France.
Jérome AmiaudINSERM, UMR-1238, Equipe 1, Faculté de Médecine, Université de Nantes, F-44035 Nantes, France.
Sylvie BabajkoCentre de Recherche des Cordeliers, INSERM UMR-1138, Sorbonne Université, Université de Paris, Laboratoire de Physiopathologie Orale Moléculaire, F-75006 Paris, France.
Ariane BerdalCentre de Recherche des Cordeliers, INSERM UMR-1138, Sorbonne Université, Université de Paris, Laboratoire de Physiopathologie Orale Moléculaire, F-75006 Paris, France.
Ana Carolina AcevedoLaboratory of Oral Histopathology, Health Sciences Faculty, University of Brasília, Brasília 70910-900, Brazil.ORCID 0000-0001-7110-7110
Dominique HeymannINSERM, LEA Sarcoma Research Unit, University of Sheffield, Department of Oncology and Human Metabolism, Medical School, Sheffield S10 2RX, UK.ORCID 0000-0001-7777-0669
Frédéric LézotINSERM, UMR-1238, Equipe 1, Faculté de Médecine, Université de Nantes, F-44035 Nantes, France.ORCID 0000-0001-6274-6981
Beatriz CastanedaService d'Odontologie-Stomatologie, Hôpital Pitié-Salpêtrière, AP-HP, F-75013 Paris, France.
Inserm · FRUniversidade de Brasília · BRSorbonne Université · FR

Funding

Bone Cancer Research Trust 144681Institut National de la Santé et de la Recherche Médicale RecurentInstitut National Du Cancer 6001Ligue Nationale contre le Cancer Financement 2018-19 CGO comités 22, 44 et 49SFODF (Société Française d'Orthodontie Dento-Faciale Prix Recherche 2017-18University Paris-Diderot Recurent
6 · The paper itself

Abstract

The purpose of the present study was to assess the early stages of development of mouse first molar roots in the osteopetrotic context of RANKL invalidation in order to demonstrate that the radicular phenotype observed resulted not only from defective osteoclasts, but also from loss of cell-to-cell communication among dental, periodontium and alveolar bone cells involving RANKL signaling. Two experimental models were used in this study:

Indexed as

HomozygoteMutationAnimalsBiomarkersGene ExpressionGenotypeImmunohistochemistryMiceOdontogenesisPhenotypeRANK LigandTooth RootBiomarkersRANK LigandTnfsf11 protein, mousebone resorptionHertwig’s epithelial root sheathRANKL/RANK signalingroot formationtooth

Identifiers

PMID32209985
PMCPMC7139335
OpenAlexW3012620604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.