ArticlePsychiatry investigation2020
Understanding the Complex of Suicide in Depression: from Research to Clinics.
Article in Psychiatry investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers, 11 of them syntheses that pooled it.
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Who cites it
190 citing papers in PubMed, 11 syntheses or guidelines pooled it, 385 citations in OpenAlex.
- Interleukin-1β (C-511T) Genetic Variant and Major Depressive Disorder: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- The association between white matter hyperintensities and suicide attempts in affective disorders: a systematic review and meta-analysis.Translational psychiatry · 2025Pooled it
- ADHD and Suicidality in Adolescents: A Systematic Review of Moderators and Mediators.Clinical child and family psychology review · 2025Pooled it
- Stigma and health outcomes in multiple sclerosis: a systematic review.BMC neurology · 2024Pooled it
- Glial Markers of Suicidal Behavior in the Human Brain-A Systematic Review of Postmortem Studies.International journal of molecular sciences · 2024Pooled it
- Bibliometric insights into astrocytic roles in depression and treatment.Frontiers in cellular neuroscience · 2024Pooled it
- Effectiveness of horticultural therapy in aged people with depression: A systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Hospital presenting suicidal ideation: A systematic review.Clinical psychology & psychotherapy · 2022Pooled it
- Role of dietary factors in the prevention and treatment for depression: an umbrella review of meta-analyses of prospective studies.Translational psychiatry · 2021Pooled it
- Effectiveness of Smartphone-Based Cognitive Behavioral Therapy Among Patients With Major Depression: Systematic Review of Health Implications.JMIR mHealth and uHealth · 2021Pooled it
- Red and Processed Meat Consumption and Risk of Depression: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- ANK3 as a Novel Genetic Biomarker for Liafensine in Treatment-Resistant Depression: The ENLIGHTEN Randomized Clinical Trial.JAMA psychiatry · 2025Trial
- Prevalence and Clinical Correlates of Suicide Attempts Among Young Patients With Major Depressive Disorder With Subclinical Hypothyroidism: A Cross-Sectional Study.Brain and behavior · 2026Article
- A Preliminary Investigation of Going Online for Suicide-Related Reasons: The Impact on Suicide Risk and Prevention.Behavioral sciences (Basel, Switzerland) · 2026Article
- Socioeconomic Deprivation's Effect on Depression: Family Satisfaction's Moderating Role.Behavioral sciences (Basel, Switzerland) · 2026Article
- A bibliometric analysis of global research trends and emerging hotspots on suicide and depression among children and adolescents.Discover mental health · 2026Review
- Large-scale proteomic analyses before depression diagnosis reveal novel pathophysiological insights.Molecular psychiatry · 2026Article
- Depression as a Disease of White Matter Network Disruption: Learning From Multiple Sclerosis.Biological psychiatry · 2026Review
- Sad emotion processing-related theta oscillation patterns link suicide attempt to childhood trauma in depression: evidence from MEG.Translational psychiatry · 2026Article
- Meals that heal: a randomized controlled trial testing the feasibility of commercial meal delivery as a convenient dietary intervention for depression.Scientific reports · 2026Article
130 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAmongst psychiatric disorders, major depressive disorder (MDD) is the most prevalent, by affecting approximately 15-17% of the population and showing a high suicide risk rate equivalent to around 15%. The present comprehensive overview aims at evaluating main research studies in the field of MDD at suicide risk, by proposing as well as a schematic suicide risk stratification and useful flow-chart for planning suicide preventive and therapeutic interventions for clinicians.
methodsA broad and comprehensive overview has been here conducted by using PubMed/Medline, combining the search strategy of free text terms and exploded MESH headings for the topics of 'Major Depressive Disorder' and 'Suicide' as following: ((suicide [Title/Abstract]) AND (major depressive disorder [Title/Abstract])). All articles published in English through May 31, 2019 were summarized in a comprehensive way.
resultsDespite possible pathophysiological factors which may explain the complexity of suicide in MDD, scientific evidence supposed the synergic role of genetics, exogenous and endogenous stressors (i.e., interpersonal, professional, financial, as well as psychiatric disorders), epigenetic, the hypothalamic-pituitary-adrenal stress-response system, the involvement of the monoaminergic neurotransmitter systems, particularly the serotonergic ones, the lipid profile, neuro-immunological biomarkers, the Brain-derived neurotrophic factor and other neuromodulators.
conclusionThe present overview reported that suicide is a highly complex and multifaceted phenomenon in which a large plethora of mechanisms could be variable implicated, particularly amongst MDD subjects. Beyond these consideration, modern psychiatry needs a better interpretation of suicide risk with a more careful assessment of suicide risk stratification and planning of clinical and treatment interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.