ArticleNeural regeneration research2020
Regional volume changes of the brain in migraine chronification.
Article in Neural regeneration research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Aberrant Spontaneous Low-Frequency Brain Activity in Migraine: A Meta-Analysis of Resting-State fMRI Studies.Journal of neuroimaging : official journal of the American Society of NeuroimagingPooled it
- Longitudinal changes in functional connectivity and pain-induced brain activations in patients with migraine: a functional MRI study pre- and post- treatment with Erenumab.The journal of headache and pain · 2022Trial
- Differences in gray matter volume in episodic migraine patients with and without prior diagnosis or clinical care: a cross-sectional study.The journal of headache and pain · 2021Trial
- Iron concentration in the ventral pallidum of chronic migraine with medication-overuse headache.The journal of headache and pain · 2026Article
- Handcrafted MRI radiomics of enlarged perivascular spaces and machine learning predict cognitive impairment and sleep disturbance in young adults.Scientific reports · 2026Article
- Interictal eye movement alterations in migraine with aura: impact of perceptual and cognitive load during reading.The journal of headache and pain · 2025Article
- Evidence for brain glial activity in chronic migraine patients: a [European journal of nuclear medicine and molecular imaging · 2025Article
- Comprehensive Segmentation of Gray Matter Structures on T1-Weighted Brain MRI: A Comparative Study of Convolutional Neural Network, Convolutional Neural Network Hybrid-Transformer or -Mamba Architectures.AJNR. American journal of neuroradiology · 2025Article
- MRI quantified enlarged perivascular space volumes as imaging biomarkers correlating with severity of anxiety depression in young adults with long-time mobile phone use.Frontiers in psychiatry · 2025Article
- MRI-based machine learning analysis of perivascular spaces and their link to sleep disturbances, dementia, and mental distress in young adults with long-time mobile phone use.Frontiers in neuroscience · 2025Article
- Mind the Metabolic Gap: Bridging Migraine and Alzheimer's disease through Brain Insulin Resistance.Aging and disease · 2024Review
- Cortical Sulcal Abnormalities Revealed by Sulcal Morphometry in Patients with Chronic and Episodic Migraine.Journal of pain research · 2024Article
- Mechanism of Traditional Chinese Medicine in Treating Migraine: A Comprehensive Review.Journal of pain research · 2024Review
- Thalamic subfield iron accumulation after acute mild traumatic brain injury as a marker of future post-traumatic headache intensity.Headache · 2023Observational
- Impairments to the multisensory integration brain regions during migraine chronification: correlation with the vestibular dysfunction.Frontiers in molecular neuroscience · 2023Article
- Pathophysiology of Chronic Migraine: Insights from Recent Neuroimaging Research.Current pain and headache reports · 2022Review
- A c-Fos activation map in nitroglycerin/levcromakalim-induced models of migraine.The journal of headache and pain · 2022Article
- Migraine and peripheral pain models show differential alterations in neuronal complexity.Headache · 2022Article
- Hypoperfusion in nucleus accumbens in chronic migraine using 3D pseudo-continuous arterial spin labeling imaging MRI.The journal of headache and pain · 2022Article
- Early Onset Diffusion Abnormalities in Refractory Headache Disorders.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathophysiology of migraine is complex. Neuroimaging studies reveal functional and structural changes in the brains of migraine patients. We sought to explore regional volume differences in intracranial structures in patients with episodic and chronic migraine. Sixteen episodic migraine patients, 16 chronic migraine patients, and 24 normal controls were recruited and underwent 3.0 T MRI scanning. The volumes of 142 brain regions were calculated by an automatic volumetric algorithm and compared with clinical variables. Results demonstrated that the volumes of specific regions in the frontal and occipital lobes, and the right putamen, were increased and the volume of the fourth ventricle was decreased in the episodic migraine patients compared with controls. The volumes of the left basal forebrain, optic chiasm, and, the fourth ventricle were decreased in the chronic migraine patients, while the occipital cortex and the right putamen were larger. Compared to episodic migraine patiants, chronic migraine patients displayed larger left thalamus and smaller frontal regions. Correlation analysis showed that headache frequency was negatively correlated with the volume of the right frontal pole, right lateral orbital gyrus, and medial frontal lobes and positively correlated with the volume of the left thalamus. The sleep disturbance score was negatively correlated with the volume of the left basal forebrain. This suggests that migraine patients have structural changes in regions associated with pain processing and modulation, affective and cognitive processing, and visual perception. The remodeling of selective intracranial structures may be involved in migraine attacks. This study was approved by the Ethics Committee of Chinese PLA General Hospital (approval No. S2018-027-02) on May 31, 2018.
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