Evidence map›Paper›PMID 32209758›Full record

ReviewNeural regeneration research2020

Advanced diffusion magnetic resonance imaging in patients with Alzheimer's and Parkinson's diseases.

Koji Kamagata, Christina Andica, Taku Hatano, Takashi Ogawa, Haruka Takeshige-Amano, Kotaro Ogaki, Toshiaki Akashi, Akifumi Hagiwara, Shohei Fujita, Shigeki Aoki

Abstract readReview
In one paragraph

Review in Neural regeneration research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Koji KamagataDepartment of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Christina AndicaDepartment of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Taku HatanoDepartment of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Takashi OgawaDepartment of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Haruka Takeshige-AmanoDepartment of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Kotaro OgakiDepartment of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Toshiaki AkashiDepartment of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Akifumi HagiwaraDepartment of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Shohei FujitaDepartment of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Shigeki AokiDepartment of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of neurodegenerative diseases is increasing as human longevity increases. The objective biomarkers that enable the staging and early diagnosis of neurodegenerative diseases are eagerly anticipated. It has recently become possible to determine pathological changes in the brain without autopsy with the advancement of diffusion magnetic resonance imaging techniques. Diffusion magnetic resonance imaging is a robust tool used to evaluate brain microstructural complexity and integrity, axonal order, density, and myelination via the micron-scale displacement of water molecules diffusing in tissues. Diffusion tensor imaging, a type of diffusion magnetic resonance imaging technique is widely utilized in clinical and research settings; however, it has several limitations. To overcome these limitations, cutting-edge diffusion magnetic resonance imaging techniques, such as diffusional kurtosis imaging, neurite orientation dispersion and density imaging, and free water imaging, have been recently proposed and applied to evaluate the pathology of neurodegenerative diseases. This review focused on the main applications, findings, and future directions of advanced diffusion magnetic resonance imaging techniques in patients with Alzheimer's and Parkinson's diseases, the first and second most common neurodegenerative diseases, respectively.

Indexed as

Alzheimer’s diseasebiomarkersdiffusional kurtosis imagingdisease progressionearly diagnosisfree-water imagingneurite orientation dispersion and density imagingneuritesParkinson’s disease

Identifiers

PMID32209758
PMCPMC7437577

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.