Evidence map›Paper›PMID 32209691›Full record

ArticlemBio2020

Glycemic Variability in Diabetes Increases the Severity of Influenza.

Rebecca J Marshall, Pornthida Armart, Katina D Hulme, Keng Yih Chew, Alexandra C Brown, Philip M Hansbro, Conor J Bloxham, Melanie Flint, Katharina Ronacher, Helle Bielefeldt-Ohmann and 2 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 49 citations in OpenAlex.

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  8. ARRDC4-mediated glycolysis enhances innate immunity to influenza A virus through fructose-1,6-bisphosphate.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Rebecca J MarshallSchool of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, QLD, Australia.
Pornthida ArmartSchool of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, QLD, Australia.
Katina D HulmeSchool of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, QLD, Australia.
Keng Yih ChewSchool of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, QLD, Australia.
Alexandra C BrownPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW, Australia.
Philip M HansbroPriority Research Centre for Healthy Lungs, Hunter Medical Research Institute, New Lambton, NSW, Australia.
Conor J BloxhamSchool of Biomedical Sciences, The University of Queensland, St. Lucia, QLD, Australia.ORCID 0000-0003-1469-8174
Melanie FlintSchool of Biomedical Sciences, The University of Queensland, St. Lucia, QLD, Australia.
Katharina RonacherMater Research Institute, Translational Research Institute, The University of Queensland, Woolloongabba, QLD, Australia.
Helle Bielefeldt-OhmannSchool of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, QLD, Australia.
Linda A GalloSchool of Biomedical Sciences, The University of Queensland, St. Lucia, QLD, Australia.
Kirsty R ShortSchool of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, QLD, Australia k.short@uq.edu.au.
The University of Queensland · AUTranslational Research Institute · AUHunter Medical Research Institute · AUUniversity of Technology Sydney · AU

Funding

New York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8M
NIDDK NIH HHS P30 DK111022
6 · The paper itself

Abstract

People with diabetes are two times more likely to die from influenza than people with no underlying medical condition. The mechanisms underlying this susceptibility are poorly understood. In healthy individuals, small and short-lived postprandial peaks in blood glucose levels occur. In diabetes mellitus, these fluctuations become greater and more frequent. This glycemic variability is associated with oxidative stress and hyperinflammation. However, the contribution of glycemic variability to the pathogenesis of influenza A virus (IAV) has not been explored. Here, we used an

Indexed as

Severity of Illness IndexAnimalsBiomarkersBlood GlucoseCell DeathCells, CulturedCoculture TechniquesDiabetes Mellitus, Type 2Endothelial CellsGlycemic LoadHumansInflammationInfluenza A virusInfluenza, HumanMaleMiceBiomarkersBlood Glucoseblood glucosediabetesinfluenza

Identifiers

PMID32209691
PMCPMC7157527
OpenAlexW3013556927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.