ArticleProceedings of the National Academy of Sciences of the United States of America2020
Compartmentalized processing of catechols during mussel byssus fabrication determines the destiny of DOPA.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 73 citations in OpenAlex.
- Underwater self-curing and adhesion of phenolic polymer coacervate with negligible external stimuli.Materials today. Bio · 2026Article
- Biomedical Potential of the Deep-Sea Vent MusselMarine drugs · 2026Review
- Adverse outcome pathways of titanium dioxide nanoparticles and marine heatwaves on byssal performance in mussels.Eco-Environment & Health · 2026Article
- A natural solution from caterpillar cuticles for flexible impact-resistant materials.Nature communications · 2026Article
- Binding Mode Analysis of Antifouling Compounds Targeting Tyrosinase and Acetylcholinesterase by Saturation Transfer Difference NMR Spectroscopy.Chembiochem : a European journal of chemical biology · 2026Article
- Histidine-rich coiled-coils promote zinc-dependent self-assembly and curing of porous mussel glues.Nature communications · 2026Article
- Catechol redox maintenance in mussel adhesion.Nature reviews. Chemistry · 2025Review
- Mussel-inspired cross-linking mechanisms enhance gelation and adhesion of multifunctional mucin-derived hydrogels.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Pharmacological effects and application prospects of mussel adhesive proteins.Frontiers in pharmacology · 2025Review
- Diversity and evolution of tyrosinase enzymes involved in the adhesive systems of mussels and tubeworms.iScience · 2024Article
- An Overview on the Adhesion Mechanisms of Typical Aquatic Organisms and the Applications of Biomimetic Adhesives in Aquatic Environments.International journal of molecular sciences · 2024Review
- Molecular Crowding: The History and Development of a Scientific Paradigm.Chemical reviews · 2024Review
- Molecular design of an ultra-strong tissue adhesive hydrogel with tunable multifunctionality.Bioactive materials · 2023Article
- Protein-Based Biological Materials: Molecular Design and Artificial Production.Chemical reviews · 2023Review
- A Visible Light-Induced and ROS-Dependent Method for the Rapid Formation of a MOF Composite Membrane with Antibacterial Properties.International journal of molecular sciences · 2023Article
- Smart bioadhesives for wound healing and closure.Bioactive materials · 2023Review
- High Performance Marine and Terrestrial Bioadhesives and the Biomedical Applications They Have Inspired.Molecules (Basel, Switzerland) · 2022Review
- Semi-Biosynthetic Production of Surface-Binding Adhesive Antimicrobial Peptides Using Intein-Mediated Protein Ligation.International journal of molecular sciences · 2022Article
- Synthetic biology as driver for the biologization of materials sciences.Materials today. Bio · 2021Review
- A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery.Nature communications · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inspired largely by the role of the posttranslationally modified amino acid dopa (DOPA) in mussel adhesion, catechol functional groups have become commonplace in medical adhesives, tissue scaffolds, and advanced smart polymers. Yet, the complex redox chemistry of catechol groups complicates cross-link regulation, hampering fabrication and the long-term stability/performance of mussel-inspired polymers. Here, we investigated the various fates of DOPA residues in proteins comprising mussel byssus fibers before, during, and after protein secretion. Utilizing a combination of histological staining and confocal Raman spectroscopy on native tissues, as well as peptide-based cross-linking studies, we have identified at least two distinct DOPA-based cross-linking pathways during byssus fabrication, achieved by oxidative covalent cross-linking or formation of metal coordination interactions under reducing conditions, respectively. We suggest that these end states are spatiotemporally regulated by the microenvironments in which the proteins are stored prior to secretion, which are retained after formation-in particular, due to the presence of reducing moieties. These findings provide physicochemical pathways toward greater control over properties of synthetic catechol-based polymers and adhesives.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.