Evidence map›Paper›PMID 32209585›Full record

ArticleBMJ open diabetes research & care2020

Association of

Aaron Leong, Victor Jun Yu Lim, Chaolong Wang, Jin-Fang Chai, Rajkumar Dorajoo, Chew-Kiat Heng, Rob M van Dam, Woon-Puay Koh, Jian-Min Yuan, Jost B Jonas and 7 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open diabetes research & care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  3. Prediabetes.Nature reviews. Disease primers · 2025
    Review
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  10. Review
  11. The quagmire of race, genetic ancestry, and health disparities.The Journal of clinical investigation · 2021
    Review
  12. Review
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 4 countries.

Aaron Leong *Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA ephsx@nus.edu.sg asleong@partners.org.
Victor Jun Yu Lim *Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Chaolong WangDepartment of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Jin-Fang ChaiSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Rajkumar DorajooGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore.
Chew-Kiat HengDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Rob M van DamSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Woon-Puay KohHealth Services and Systems Research, Duke NUS Medical School, Singapore.
Jian-Min YuanDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jost B JonasDepartment of Ophthalmology, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Baden-Württemberg, Germany.
Ya Xing WangOphthalmology and Visual Sciences Key Laboratory, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Wen-Bin WeiBeijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Jianjun LiuGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore.
Dermot F ReillyGenetics, Merck Sharp and Dohme IA, Kenilworth, New Jersey, USA.
Tien-Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Xueling SimSaw Swee Hock School of Public Health, National University of Singapore, Singapore ephsx@nus.edu.sg asleong@partners.org.ORCID 0000-0002-1233-7642
National University of Singapore · SGAgency for Science, Technology and Research · SGBeijing Tongren Hospital · CNSingapore National Eye Center · SGDuke-NUS Medical School · SGHarvard University · USMerck & Co., Inc., Rahway, NJ, USA (United States) · USUniversity of Pittsburgh · US

Funding

Prospective studies of cancer etiology and prevention in Shanghai and SingaporeR01CA144034 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2010 to 2014
$7.0M
THE SINGAPORE COHORT STUDY OF DIET AND CANCERR01CA080205 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YUAN, JIAN-MIN · 1999 to 2009
$5.3M
Cancer epidemiology cohorts in Shanghai and Singapore UM1CA182876 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2014 to 2018
$4.3M
NCI NIH HHS R01 CA080205NCI NIH HHS R01 CA144034NCI NIH HHS UM1 CA182876
6 · The paper itself

Abstract

objectiveHemoglobin A1c (HbA1c) accuracy is important for diabetes diagnosis and estimation of overall glycemia. The RESEARCH DESIGN AND

methodsIn eight Asian population-based cohorts, we performed imputation on the X chromosome using the 1000 Genomes reference panel and tested for association with HbA1c (10 005 East Asians and 2051 South Asians). Results were meta-analyzed across studies. We compared the proportion of individuals classified as having diabetes/pre-diabetes by fasting glucose ≥100 mg/dL or HbA1c ≥5.7% units among carriers and non-carriers of HbA1c-associated variants.

resultsThe strongest association was a missense variant (

conclusionsWe identified two

Indexed as

Diabetes MellitusGlucosephosphate DehydrogenaseAsian PeopleBlood GlucoseGlycated HemoglobinHumansMaleBlood GlucoseGlucosephosphate DehydrogenaseGlycated HemoglobinA1CAsiandiagnostic criteriagenetic association

Identifiers

PMID32209585
PMCPMC7103857
OpenAlexW3013967575

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.