ArticleEnvironmental research2020
Metals and trace elements in relation to body mass index in a prospective study of US women.
Article in Environmental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 81 citations in OpenAlex.
- Associations between metals and anemia indicator: mixed exposure effects and mediation analysis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
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- Combination and Interaction of Seven Trace Elements and the Risk of Protein-Energy Malnutrition in School-Aged Children in Shenzhen, China.Biological trace element research · 2026Article
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- Association Between Heavy Metals Exposure and Elevated High-Sensitivity C-Reactive Protein: Mediating Role of Body Mass Index.Biomolecules · 2025Article
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- Serum Levels of Trace Elements (Magnesium, Iron, Zinc, Selenium, and Strontium) are Differentially Associated with Surrogate Markers of Cardiovascular Disease Risk in Patients with Rheumatoid Arthritis.Biological trace element research · 2025Article
- Partial Effects in Environmental Mixtures: Evidence and Guidance on Methods and Implications.Environmental health perspectives · 2025Article
- Sex-specific associations of a ferroalloy metal mixture with motor function in Italian adolescents.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Associations Between Individual and Combined Metal Exposures in Whole Blood and Kidney Function in U.S. Adults Aged 40 Years and Older.Biological trace element research · 2024Article
- Prenatal exposures to phthalates and bisphenols in relation to oxidative stress: single pollutant and mixtures analyses.Environmental science and pollution research international · 2024Article
- The Influence of Follicular Fluid Metals on Assisted Reproduction Outcome.Biological trace element research · 2023Article
- Reliability of low mass toenail samples as biomarkers of chronic metal exposure.Journal of exposure science & environmental epidemiology · 2023Article
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- Exposure to Metal Mixtures and Overweight or Obesity Among Chinese Adults.Biological trace element research · 2023Article
- The Combined Effects of Short-Term Exposure to Multiple Meteorological Factors on Unintentional Drowning Mortality: Large Case-Crossover Study.JMIR public health and surveillance · 2023Article
- Application of deep learning to predict the low serum albumin in new hemodialysis patients.Nutrition & metabolism · 2023Article
- Article
- Joint Effect of Multiple Metals on Hyperuricemia and Their Interaction with Obesity: A Community-Based Cross-Sectional Study in China.Nutrients · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEpidemiologic studies on the association between metals and body mass index (BMI) have been cross-sectional and have demonstrated inconsistent associations. Our study prospectively examined whether metals measured at baseline were associated with later BMI. We considered metals individually and as joint exposure to pre-defined metal groupings.
methodsWe measured concentrations of 16 metals in toenails collected at baseline (2003-2009) in a subset of 1221 women from the Sister Study. We calculated BMI from height and weight reported on a follow-up questionnaire an average of 5.2 years (range = 3.5-8.3) after baseline. Multivariable linear regression was used to estimate β coefficients and 95% confidence intervals (CIs) for associations between BMI and individual metals (with estimates given per interquartile range (IQR) increase or in quartiles). Quantile g-computation was used to examine joint associations between groups of metals and BMI. Groups considered were (1) all metals combined, and metals classified as (2) non-essential or (3) essential.
resultsIn individual metal models we found that, with the exception of cobalt, no single metal was strongly related to BMI. In our mixture analyses, a quartile increase in all non-essential metals was associated with higher BMI (β = 0.32; 95%CI: 0.00, 0.63 kg/m
conclusionsIn this population of women who were, on average, overweight, essential metals were jointly associated with slightly healthier, lower BMI whereas non-essential metals were jointly associated with slightly higher, unhealthier BMI, after controlling for other health indicators and predictors of metals exposures.
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