ArticleCell host & microbe2020
Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition.
Article in Cell host & microbe, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 88 citations in OpenAlex.
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- Rewilding catalyzes maturation of the humoral immune system.Science advances · 2025Article
- Article
- Genetic and environmental interactions contribute to immune variation in rewilded mice.Nature immunology · 2024Article
- Competitive fungal commensalism mitigates candidiasis pathology.The Journal of experimental medicine · 2024Article
- Female behavior drives the formation of distinct social structures in C57BL/6J versus wild-derived outbred mice in field enclosures.BMC biology · 2024Article
- Assessing immune phenotypes using simple proxy measures: promise and limitations.Discovery immunology · 2024Article
- Spatiotemporal-social association predicts immunological similarity in rewilded mice.Science advances · 2023Article
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13 authors at 4 institutions in 1 country.
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Abstract
The relative contributions of genetic and environmental factors to variation in immune responses are poorly understood. Here, we performed a phenotypic analysis of immunological parameters in laboratory mice carrying susceptibility genes implicated in inflammatory bowel disease (IBD) (Nod2 and Atg16l1) upon exposure to environmental microbes. Mice were released into an outdoor enclosure (rewilded) and then profiled for immune responses in the blood and lymph nodes. Variations of immune cell populations were largely driven by the environment, whereas cytokine production elicited by microbial antigens was more affected by the genetic mutations. We identified transcriptional signatures in the lymph nodes associated with differences in T cell populations. Subnetworks associated with responses against Clostridium perfringens, Candida albicans, and Bacteroides vulgatus were also coupled with rewilding. Therefore, exposing laboratory mice with genetic mutations to a natural environment uncovers different contributions to variations in microbial responses and immune cell composition.
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