ArticleJournal of molecular and cellular cardiology2020
Modulation of the cardiac sodium channel Na
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Article in Journal of molecular and cellular cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
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- Dual Effects of Nicotinamide on Aging-Related Arrhythmia: Protective at Low Dose, Proarrhythmic at Higher Doses.Journal of the American Heart Association · 2026Article
- Sodium Channel Isoform Diversity Underlies Chamber-Specific Cardiac Excitability.Circulation research · 2026Article
- Cardiac Sodium Channel Regulation: A Potential New Therapeutic Target in Cardiomyopathy.Circulation research · 2026Article
- Short SCN5A Transcript Yields a NaV1.5 Fragment Influencing Cardiac Metabolism.Circulation research · 2026Article
- Conventional Antiarrhythmics Class I-IV, Late INa Inhibitors, IKs Enhancers, RyR2 Stabilizers, Gap Junction Modulators, Atrial-Selective Antiarrhythmics, and Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Therapy in Arrhythmias.Pharmaceuticals (Basel, Switzerland) · 2026Review
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- Cardiac intermediary metabolism in heart failure: substrate use, signalling roles and therapeutic targets.Nature reviews. Cardiology · 2025Review
- The Role of NADAmerican journal of cardiovascular drugs : drugs, devices, and other interventions · 2025Review
- Cardiac NADNature cardiovascular research · 2024Article
- Nicotinamide Mononucleotide: Research Process in Cardiovascular Diseases.International journal of molecular sciences · 2024Review
- Role of Protein Kinase C in Metabolic Regulation of Coronary Endothelial Small Conductance Calcium-Activated Potassium Channels.Journal of the American Heart Association · 2024Article
- Knockout of Sorbin And SH3 Domain Containing 2 (Sorbs2) in Cardiomyocytes Leads to Dilated Cardiomyopathy in Mice.Journal of the American Heart Association · 2022Article
- Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome.Clinical and translational medicine · 2022Article
- Fibroblast growth factor homologous factors serve as a molecular rheostat in tuning arrhythmogenic cardiac late sodium current.Nature cardiovascular research · 2022Article
- Late Sodium Current of the Heart: Where Do We Stand and Where Are We Going?Pharmaceuticals (Basel, Switzerland) · 2022Review
- Genomic and Non-Genomic Regulatory Mechanisms of the Cardiac Sodium Channel in Cardiac Arrhythmias.International journal of molecular sciences · 2022Review
- COVID-19: the CaMKII-like system of S protein drives membrane fusion and induces syncytial multinucleated giant cells.Immunologic research · 2021Article
- NADFrontiers in physiology · 2020Review
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Authors and funding
12 authors at 1 institution in 1 country.
Daniel S MatasicDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.
Jin-Young YoonDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.
Jared M McLendonDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.
Haider MehdiDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.
Mark S SchmidtAbboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Department of Biochemistry, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.
Alexander M GreinerDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.
Pravda QuinonesDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.
Gina M MorganDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.
Ryan L BoudreauDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.
Kaikobad IraniDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.
Charles BrennerAbboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Department of Biochemistry, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.
Barry LondonDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America. Electronic address: barry-london@uiowa.edu.
University of Iowa · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9MINTERDISCIPLINARY CARDIOVASCULAR RESEARCH FELLOWSHIPT32HL007121 · NHLBI · UNIVERSITY OF IOWA · PI LONDON, BARRY · 1985 to 2020
$15.1MSUMOylation of Voltage-Gated Sodium Channels In Neuronal Hyperexcitability of Alzheimer’s DementiaR01HL115955 · NHLBI · UNIVERSITY OF IOWA · PI IRANI, KAIKOBAD J., LONDON, BARRY · 2013 to 2023
$5.4MThe SIRT1-Gpd1L-NAD+ interactome in regulation of the Neuronal Sodium Channel: Implications for Cognitive Impairment of Alzheimerâs DementiaR01HL147545 · NHLBI · UNIVERSITY OF IOWA · PI BRENNER, CHARLES M, IRANI, KAIKOBAD J. · 2019 to 2022
$2.9MRegulation and role of the cardiac sodium channel Nav1.5 in heart failureR01HL144717 · NHLBI · UNIVERSITY OF IOWA · PI BOUDREAU, RYAN L · 2019 to 2023
$1.9MThe genomic interface of microRNA regulation and heart failureR01HL148796 · NHLBI · UNIVERSITY OF IOWA · PI BOUDREAU, RYAN L · 2019 to 2022
$1.5MAssessing the Impact of MSX1 in Cardiac Fibrosis and Sudden Cardiac DeathF30HL143908 · NHLBI · UNIVERSITY OF IOWA · PI GREINER, ALEXANDER · 2018 to 2021
$152kPost-Translational Crosstalk in Cardiac Sodium Channels and ArrhythmogenesisF30HL137272 · NHLBI · UNIVERSITY OF IOWA · PI MATASIC, DANIEL STEVENS · 2018 to 2020
$116kNHLBI NIH HHS F30 HL137272NHLBI NIH HHS F30 HL143908NHLBI NIH HHS R01 HL115955NHLBI NIH HHS R01 HL144717NHLBI NIH HHS R01 HL147545NHLBI NIH HHS R01 HL148796NHLBI NIH HHS T32 HL007121NIGMS NIH HHS T32 GM007337
Abstract
rationaleThe cardiac sodium channel Na
objectiveTo determine whether and by which mechanisms the NAD METHODS AND
resultsThe effects of NAD
conclusionsNAD
Indexed as
Ion Channel GatingAcetylationAnimalsDietary SupplementsHEK293 CellsHumansLysineMetabolomeMice, Inbred C57BLMyocardiumMyocytes, CardiacNADNAV1.5 Voltage-Gated Sodium ChannelNiacinamidePhosphorylationPyridinium CompoundsLysineN(1)-methylnicotinamideNADNAV1.5 Voltage-Gated Sodium ChannelNiacinamidenicotinamide-beta-ribosidePyridinium CompoundsAcetylationArrhythmiaCardiac Sodium Channel (Na(V)1.5, SCN5A)Metabolic regulationNAD(+)/NADHNicotinamideNicotinamide ribosideSirtuins
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.