Evidence map›Paper›PMID 32209130›Full record

ReviewArthritis research & therapy2020

Post-traumatic osteoarthritis following ACL injury.

Li-Juan Wang, Ni Zeng, Zhi-Peng Yan, Jie-Ting Li, Guo-Xin Ni

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Arthritis research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  12. Decreased Thigh Muscle Cross-Sectional Area Following Anterior Cruciate Ligament Injury Depends on Concomitant Meniscal Injury and Subject Sex.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
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  18. From fracture to joint injury: association between CT-based fracture characteristics and surgically treated non-bony injuries in tibial plateau fractures.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Li-Juan WangSchool of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing, China.
Ni ZengDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Zhi-Peng YanDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Jie-Ting LiDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Guo-Xin NiSchool of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing, China. niguoxin@bsu.edu.cn.

Funding

Medical innovation project of Fujian Province (CN) 2017-CX-25National Natural Science Foundation of China 81871848
6 · The paper itself

Abstract

Post-traumatic osteoarthritis (PTOA) develops after joint injury. Specifically, patients with anterior cruciate ligament (ACL) injury have a high risk of developing PTOA. In this review, we outline the incidence of ACL injury that progresses to PTOA, analyze the role of ACL reconstruction in preventing PTOA, suggest possible mechanisms thought to be responsible for PTOA, evaluate current diagnostic methods for detecting early OA, and discuss potential interventions to combat PTOA. We also identify important directions for future research. Although much work has been done, the incidence of PTOA among patients with a history of ACL injury remains high due to the complexity of ACL injury progression to PTOA, the lack of sensitive and easily accessible diagnostic methods to detect OA development, and the limitations of current treatments. A number of factors are thought to be involved in the underlying mechanism, including structural factors, biological factors, mechanical factors, and neuromuscular factor. Since there is a clear "start point" for PTOA, early detection and intervention is of great importance. Currently, imaging modalities and specific biomarkers allow early detection of PTOA. However, none of them is both sensitive and easily accessible. After ACL injury, many patients undergo surgical reconstruction of ACL to restore joint stability and prevent excessive loading. However, convincing evidence is still lacking for the superiority of ACL-R to conservative management in term of the incidence of PTOA. As for non-surgical treatment such as anti-cytokine and chemokine interventions, most of them are investigated in animal studies and have not been applied to humans. A complete understanding of mechanisms to stratify the patients into different subgroups on the basis of risk factors is critical. And the improvement of standardized and quantitative assessment techniques is necessary to guide intervention. Moreover, treatments targeted toward different pathogenic pathways may be crucial to the management of PTOA in the future.

Indexed as

AnimalsAnterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionBiomarkersDisease Models, AnimalHumansOsteoarthritisOsteoarthritis, KneeBiomarkersAnterior cruciate ligament injuryInterventionMechanismPost-traumatic osteoarthritis

Identifiers

PMID32209130
PMCPMC7092615

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.